20308-62-7Relevant academic research and scientific papers
Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp3)–H Borylation of Acyclic Amides
Yang, Yuhuan,Chen, Lili,Xu, Senmiao
supporting information, p. 3524 - 3528 (2020/12/15)
We herein report amide directed enantioselective β-C(sp3)?H borylation of unbiased methylene C?H bonds of acyclic amides enabled by iridium catalysis for the first time. The key to the success of this transformation relies on the careful select
Diboron-Mediated Rhodium-Catalysed Transfer Hydrogenation of Alkenes and Carbonyls
Lin, Xiao,Wang, Yuhan,Hu, Yan,Zhu, Wanjiang,Dou, Xiaowei
supporting information, p. 1046 - 1049 (2020/02/25)
A diboron-mediated rhodium-catalysed transfer hydrogenation system using water as the hydrogen donor is developed. In addition to a series of alkenes with good functional group tolerance, this rhodium-based catalytic system also effectively reduces aldehydes and ketones. A plausible mechanism involving the RhI-catalysed hydrogen generation and Rh0-catalysed hydrogenation is proposed for the reaction.
Carboxamidation of carboxylic acids with 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI) without bases
Saito, Yukako,Ouchi, Hidekazu,Takahata, Hiroki
experimental part, p. 11129 - 11135 (2009/04/11)
Formation of carboxamides of a variety of carboxylic acids with the coupling reagent BBDI is described. This procedure permits a one pot and simple operation without the need of any bases and no base was?required for even use of amine hydrochlorides. In addition, an approach to BBDI-catalyzed carboxamidation is examined.
N-hydroxypyridine-2(1H)-thione derivatives of carboxylic acids as activated esters. Part I. The synthesis of carboxamides
Barton, Derek H. R.,Ferreira, J. Albert
, p. 9347 - 9366 (2007/10/03)
The reaction between an acyl derivative of N-hydroxypyridine-2(1H)- thione (a Barton PTOC ester) and either an amine (primary or secondary), or the corresponding sulfenamide, led to the formation of a carboxamide in a clean transformation requiring minimal work-up and purification. The reaction with a sulfenamide is particularly useful since the only by-product, an unsymmetrical disulfide, is of both synthetic and biological value. In sterically demanding cases, Barton PTOC esters were more reactive towards benzenesulfenamides than to the corresponding free amines.
Facile synthesis of α-hydroxy amides and esters by direct autoxidation of their titanium enolates
Adam,Metz,Prechtl,Renz
, p. 563 - 566 (2007/10/02)
The autoxidation of titanium enolates 2, derived from amides and esters 1, afforded either directly the corresponding α-hydroxy carbonyl compounds 3 or, by variation of the reaction conditions, the γ-hydroxy β-keto ester 4 from ester 1g in good yields (64
