20309-87-9 Usage
Uses
Used in Organic Synthesis:
4-methyleneproline is used as a building block in organic synthesis for its enhanced reactivity due to the addition of a methylene group, which facilitates the construction of complex molecular structures.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-methyleneproline is utilized as a key component for the development of new drugs. Its unique properties allow for the design of molecules with altered conformations and stabilities, potentially leading to more effective pharmaceutical agents.
Used in Drug Design and Development:
4-methyleneproline is employed as a structural modifier in drug design and development, providing novel opportunities for creating biologically active molecules with improved pharmacological properties.
Used in the Synthesis of Bioactive Natural Products and Pharmaceuticals:
4-methyleneproline is also used in the synthesis of bioactive natural products and pharmaceuticals, where its unique structural attributes contribute to the discovery of new therapeutic agents with potential applications in various medical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 20309-87-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,3,0 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 20309-87:
(7*2)+(6*0)+(5*3)+(4*0)+(3*9)+(2*8)+(1*7)=79
79 % 10 = 9
So 20309-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NO2/c1-4-2-5(6(8)9)7-3-4/h5,7H,1-3H2,(H,8,9)/t5-/m0/s1
20309-87-9Relevant academic research and scientific papers
Mazon, Angel,Najera, Carmen
, p. 1855 - 1859 (1997)
The enantiomerically pure glycine derivative tert-butyl (S)-2-(tert-butyl)-3-methyl-4-oxo-l-imidazolidinecarboxylate (Boc-BMI) reacts with (Z)-1,4-dichloro-2-butene and 3-chloro-2-(chloromethyl)-1-propene to give the bicyclic intermediates 5 and 6, respectively. These dialkylated systems are hydrolyzed to the corresponding heterocyclic a-amino acids (S)-baikiain (L-4,5-didehydropipecolic acid) and (S)-4-methylene proline which are obtained in 96 and 90% ee, respectively.
A Short and Efficient Synthesis of (S)-4-Methylene Proline Benzyl Ester from (S)-Pyroglutamic Acid
Panday, Sharad Kumar,Griffart-Brunet, Dominique,Langlois, Nicole
, p. 6673 - 6676 (2007/10/02)
(S)-4-methylene proline benzyl ester 2 was synthesized from benzyl N-tert-butoxycarbonyl pyroglutamate through a Mannich and a Cope elimination reactions.
A radical route to 2(s)-4-exomethylene proline
Adlington, Robert M.,Mantell, Simon J.
, p. 6529 - 6536 (2007/10/02)
A new route to 2(S)-4-Ethomethylene proline via a favoured 5-Exo-dig radical cyclisation is described.
