2031161-35-8

Basic information

• Product Name: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide
• CAS NO: 2031161-35-8
• Molecular Weight: 405.352
• Mol File: 2031161-35-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide(2031161-35-8)
• EPA Substance Registry System: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide(2031161-35-8)

Safety Data

• Hazardous Substances Data: 2031161-35-8(Hazardous Substances Data)

Usage

General Description

(2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide is a chemical compound with the molecular formula C20H19F4N3O2. (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide is a synthetic organic molecule that contains a phenyl group with a cyano (CN) and trifluoromethyl (CF3) substituents, as well as an indolyl group with a fluorine (F) substituent. The compound also contains an amide functional group, which is attached to a chiral carbon, giving the molecule a specific stereochemistry. (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide may have potential applications in pharmaceutical research and drug development due to its unique structure and biological activity.

Upstream product

• 113181-02-5 (S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide 
• 206193-17-1 (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 399-52-0 5-fluoro-1H-indole 
• 512776-95-3 (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide 
• 1019972-88-3 (R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide 

Relevant articles and documents

New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

In our effort to find small-molecule treatments of advanced prostate cancers (PCs), a novel series of indolyl and indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders (SARDs). Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. Cyclization to II and III produced submicromolar AR antagonism and protein degradation selective to AR and AR splice variant (AR SV). II and III maintained potency against enzalutamide-resistant (Enz-R) mutant ARs and PC cells and were efficacious in Enz-R xenografts, suggesting their potential to treat advanced PCs. Design, synthesis, and biological activity of novel SARDs that could potentially be used for the treatment of a wide spectrum of PCs including castration-resistant, Enz-R, and/or AR SV-dependent advanced PCs that are often untreatable with known hormone therapies are discussed.