203121-40-8Relevant academic research and scientific papers
A boron-oxygen transborylation strategy for a catalytic midland reduction
Nicholson, Kieran,Dunne, Joanne,DaBell, Peter,Garcia, Alexander Beaton,Bage, Andrew D.,Docherty, Jamie H.,Hunt, Thomas A.,Langer, Thomas,Thomas, Stephen P.
, p. 2034 - 2040 (2021/02/20)
The enantioselective hydroboration of ketones is a textbook reaction requiring stoichiometric amounts of an enantioenriched borane, with the Midland reduction being a seminal example. Here, a turnover strategy for asymmetric catalysis, boron.oxygen transb
Green and efficient synthesis method of chiral alkynol
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Paragraph 0050-0052, (2020/02/14)
The invention relates to a method for preparing alkynol in the technical field of chemical engineering, which is characterized in that in ethanol and formate, under the catalysis of an iridium catalyst of a chiral spiro pyridylaminophosphine ligand, acety
Iridium-Catalyzed Asymmetric Transfer Hydrogenation of Alkynyl Ketones Using Sodium Formate and Ethanol as Hydrogen Sources
Zhang, Yang-Ming,Yuan, Ming-Lei,Liu, Wei-Peng,Xie, Jian-Hua,Zhou, Qi-Lin
supporting information, p. 4486 - 4489 (2018/08/09)
A green and efficient iridium-catalyzed asymmetric transfer hydrogenation of alkynyl ketones to chiral propargylic alcohols has been developed. By using sodium formate and ethanol as hydrogen sources, a series of alkynyl ketones were hydrogenated by chira
Utilization of whole cell mediated deracemization in a chemoenzymatic synthesis of enantiomerically enriched polycyclic chromeno[4,3-b] pyrrolidines
Saravanan, Thangavelu,Jana, Sushital,Chadha, Anju
, p. 4682 - 4690 (2014/06/24)
Various aryl and alkyl substituted optically pure propargyl alcohols were obtained with excellent ee (up to >99%) and isolated yields (up to 87%) by deracemization using whole cells of Candida parapsilosis ATCC 7330. The whole cells show substrate specificity towards alkyl substituted propargyl alcohols and a switch in the enantioselectivity has been observed from 'R' to 'S' upon increasing the chain length. For the first time, enantiopure (R)-4-(3-hydroxybut-1-ynyl)benzonitrile, (R)-4-(biphenyl-4-yl)but-3-yn-2-ol, (S)-ethyl 3-hydroxy-5-phenylpent-4-ynoate and (S)-4-phenylbut-3-yne-1,2-diol were obtained using this strategy. Optically pure propargyl alcohol thus obtained was used as a chiral starting material in the synthesis of enantiomerically enriched poly-substituted pyrrolidines and a pyrrole derivative successfully demonstrating a chemoenzymatic route. This journal is
