Welcome to LookChem.com Sign In|Join Free

CAS

  • or

203127-13-3

cyclohexylidene-N-hydroxymethylsuccinimide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

203127-13-3 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 203127-13-3 Structure

  • Basic information

    1. Product Name: cyclohexylidene-N-hydroxymethylsuccinimide
    2. Synonyms: cyclohexylidene-N-hydroxymethylsuccinimide
    3. CAS NO:203127-13-3
    4. Molecular Formula:
    5. Molecular Weight: 209.245
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 203127-13-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: cyclohexylidene-N-hydroxymethylsuccinimide(CAS DataBase Reference)
    10. NIST Chemistry Reference: cyclohexylidene-N-hydroxymethylsuccinimide(203127-13-3)
    11. EPA Substance Registry System: cyclohexylidene-N-hydroxymethylsuccinimide(203127-13-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 203127-13-3(Hazardous Substances Data)

203127-13-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 203127-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,1,2 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 203127-13:
(8*2)+(7*0)+(6*3)+(5*1)+(4*2)+(3*7)+(2*1)+(1*3)=73
73 % 10 = 3
So 203127-13-3 is a valid CAS Registry Number.

203127-13-3Relevant articles and documents

Ester prodrugs of ampicillin tailored for intracellular accumulation

Fan,Paternotte,Vermander,Li,Beaujean,Scorneaux,Dumont,Osinski,Claesen,Tulkens,Sonveaux

, p. 3107 - 3112 (1997)

Seven new ester prodrugs of ampicillin with hydrolysis half-lives ranging from 65 to 308 min were synthesized. The cellular accumulation of two of them (in J774 mouse macrophages) and their activities against intracellular Staphylococcus aureus were determined in comparison with the pivaloyloxymethylester of ampicillin (pivampicillin) and ampicillin. The esters accumulated extensively and were more active than ampicillin in this in vitro system.

Syntheses and hydrolysis of basic and dibasic ampicillin esters tailored for intracellular accumulation

Paternotte, Isabelle,Fan, Hua Juan,Screve, Pascal,Claesen, Michel,Tulkens, Paul M,Sonveaux, Etienne

, p. 493 - 502 (2007/10/03)

Readily hydrolysable basic and dibasic esters of ampicillin were synthesised by alkylation of the carboxylate function of ampicillin to obtain prodrugs that may accumulate in cells and allow for an intracellular delivery of ampicillin (Fan et al., Bioorg. Med. Chem. Lett. 1997, 7, 3107). We found that the β-lactam ring cleavage and the hydrolysis of the ester function were competitive reactions. The prerequisite for biological activity of compounds of this type is therefore that ester hydrolysis proceeds faster than ring opening. Some synthesised compounds show promise as prodrugs since they displayed a reasonable stability and regenerate large quantities of bioactive ampicillin in broth.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 203127-13-3