203173-70-0Relevant academic research and scientific papers
Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals
Du, Wu,Kaskar, Bashir,Blumbergs, Peter,Subramanian,Curran, Dennis P.
, p. 451 - 458 (2007/10/03)
Thiol- or acid-promoted additions of silyl radicals to camptothecin are reported. At 105°C, mixtures of 7-silyl (favored) and 12-silyl camptothecins are formed alongside substantial amounts of recovered camptothecin. At 160°C, 12-silyl isomers are formed
Synthesis of silyl camptothecins and silyl homocamptothecins
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Example 1j, (2008/06/13)
A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor under conditions to generate a silyl radical. SiR1R2R3wherein R1, R2and R3are independently a C1-10alkyl group, a C2-10alkenyl group, a C2-10alkynyl group, an aryl group, —(CH2)mR11or SiR12R13R14, wherein m is an integer within the range of 1 through 10 and R11is a hydroxy group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, F, Cl, a cyano group, —SRcor a nitro group, and wherein R12, R13and R14are independently the same or different an alkyl group or an aryl group.
