203177-72-4Relevant academic research and scientific papers
Solution-phase synthesis of novel linear oxyamine combinatorial libraries with antibacterial activity
Kung, Pei-Pei,Bharadwaj, Ramesh,Fraser, Allister S.,Cook, Daniel R.,Kawasaki, Andrew M.,Cook, P. Dan
, p. 1846 - 1852 (2007/10/03)
Use of solution phase combinatorial library synthesis led to the discovery of several oxyaminecontaining antibacterial compounds. Solution-phase simultaneous addition of meta-substituted benzyl bromides and 'fix-last' combinatorial strategies were used to prepare libraries. Additional structure-activity relationship studies were conducted by reductive cleavage of the oxyamine moiety and led to loss of antibacterial activity. Several single compounds were designed and synthesized on the basis of library screening results and were shown to have antibacterial activity.
