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METHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE, commonly referred to as MADAM, is a versatile chemical compound characterized by its molecular formula C10H15NO3. It presents as a colorless to pale yellow liquid and is widely recognized for its high reactivity, which allows it to participate in a range of chemical reactions. MADAM is primarily utilized as a monomer in polymer and copolymer production, and also serves as a key building block in the synthesis of pharmaceuticals and other fine chemicals. Due to its potential health risks, it is crucial to handle MADAM with caution, ensuring proper ventilation and safety measures during its use.

203186-56-5

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203186-56-5 Usage

Uses

Used in Polymer and Copolymer Production:
METHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE is used as a monomer for its ability to polymerize and form various polymers and copolymers. Its high reactivity makes it a valuable component in the creation of materials with specific properties for different applications.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, METHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE is used as a building block for the synthesis of various pharmaceuticals. Its role in creating the molecular structures of drugs highlights its importance in medicinal chemistry.
Used in Organic Synthesis:
METHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE is utilized as an intermediate in organic synthesis across multiple chemical industries. Its capacity to undergo multiple chemical reactions makes it instrumental in the development of a wide array of chemical products.
Used in Fine Chemicals Production:
METHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE is also used as a component in the production of fine chemicals, where its reactivity and versatility contribute to the synthesis of specialty chemicals for various applications.
Safety Precautions:
When handling METHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE, it is essential to use it in a well-ventilated area and to follow proper safety protocols to mitigate potential health hazards associated with its use.

Check Digit Verification of cas no

The CAS Registry Mumber 203186-56-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,1,8 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 203186-56:
(8*2)+(7*0)+(6*3)+(5*1)+(4*8)+(3*6)+(2*5)+(1*6)=105
105 % 10 = 5
So 203186-56-5 is a valid CAS Registry Number.

203186-56-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-(dimethylaminomethylidene)-3-oxobutanoate

1.2 Other means of identification

Product number -
Other names methyl 2-[(dimethylamino)methylene]acetoacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:203186-56-5 SDS

203186-56-5Relevant academic research and scientific papers

GPR52 MODULATOR COMPOUNDS

-

Page/Page column 68-69, (2021/09/17)

The disclosures herein relate to novel compounds of Formula (1): and salts thereof, wherein X, Y, R1, R2, R3 and R4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.

Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries

Gorobets, Nikolay Yu.,Yousefi, Behrooz H.,Belaj, Ferdinand,Kappe, C. Oliver

, p. 8633 - 8644 (2007/10/03)

2-Pyridone and 2-quinolone analogues are well-known biologically active heterocyclic scaffolds. Libraries of 3,5,6-substituted 2-pyridone derivatives are generated by rapid microwave assisted solution phase methods using a one-pot, two-step protocol. The three-component condensation of CH-acidic carbonyl compounds, N,N-dimethylformamide dimethylacetal and methylene active nitriles, leads to 2-pyridones and fused analogues in moderate to good overall yields and high purities. The proposed mechanism of this novel multi-component reaction, structure elucidation of products and intermediates are discussed.

Practical synthesis of a new analytical construct: Thiopyrimidine safety-catch linker for facile monitoring of solid-phase chemistry

Lorthioir,McKeown,Parr,Washington,Watson

, p. 8609 - 8613 (2007/10/03)

We report here a new analytical construct based on a thiopyrimidine safety-catch linker. This construct adds to the existing portfolio of linkers available for facile monitoring of reactions conducted on solid support. A practical solution phase synthesis of the precursor is described, together with the proof of concept and cleavage protocols. (C) 2000 Elsevier Science Ltd.

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