203198-46-3

Upstream product

• 1167493-77-7 (1E)-1-{1-[4-(methylsulfonyl)phenyl]ethylidene}-2-phenylhyldrazine 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 203198-39-4 4-(methylsulfonyl)acetophenone phenylhydrazone 

Downstream Products

• 1351939-93-9 2-amino-4-(2-(4-(methylsulfonyl)phenyl)-1H-indol-3-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 1351939-94-0 2-amino-7,7-dimethyl-4-(2-(4-(methylsulfonyl)phenyl)-1H-indol-3-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 1351939-78-0 C₁₆H₁₃NO₃S 

Relevant academic research and scientific papers

Microwave-Assisted synthesis of 30-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3- carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study. Springer Science+Business Media, LLC 2011.

Design and synthesis of some 5-substituted-2-(4-(azido or methylsulfonyl)phenyl)-1h-indole derivatives as selective cyclooxygenase (cox-2) inhibitors

A group of 5-substituted-2-(4-azido or (methylsulfonyl)phenyl)-1H-indoles were designed and synthesized as selective cyclooxygenase (COX-2) inhibitors. In vitro COX-1 and COX-2 isozyme inhibition studies were carried out to investigate the effect of different substituents (H, F, CI, Me, OMe) at C-5 position and different pharmacophore groups (azido or methylsulfonyl) at para position of phenyl ring at C-2 position of the 1H-indole ring on COX-2 selectivity and potency. The structure-activity relationship study of these compounds indicated that the introduction of a methoxy substituent at C-5 position and 4-(methylsulfonyl) phenyl group at C-2 position of the 1H-indole ring (compound 4e) had the best COX-2 selectivity (S.I = 291.2). A molecular modeling study where 4e was docked in the binding site of COX-2 showed that the methylsulfonyl group at para position of phenyl ring is oriented in the vicinity of the COX-2 secondary pocket. Osterrechische Apotheker- Verlagsgedellschaft m.b.H.