20320-27-8Relevant academic research and scientific papers
Optimization of HNO production from N, O - Bis -acylated hydroxylamine derivatives
Sutton, Art D.,Williamson, Morgan,Weismiller, Hilary,Toscano, John P.
, p. 472 - 475 (2012/03/26)
A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.
