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o-(piperidinocarbonyl)-benzoic acid, a member of the benzoic acid family, is a chemical compound featuring a piperidinocarbonyl group attached at the ortho position to the benzene ring. This derivative of benzoic acid is recognized for its potential biological activity and is widely utilized in organic synthesis and medicinal chemistry as a key building block for the creation of pharmaceuticals and other organic compounds. Its versatility in chemical reactions and capacity to contribute to the development of new drugs make it a valuable asset in the scientific community.

20320-44-9

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20320-44-9 Usage

Uses

Used in Pharmaceutical Industry:
o-(piperidinocarbonyl)-benzoic acid is used as a building block for the synthesis of various pharmaceuticals due to its potential biological activity and structural properties that can be leveraged in drug development.
Used in Organic Synthesis:
o-(piperidinocarbonyl)-benzoic acid is employed as a key intermediate in the organic synthesis of complex organic molecules, contributing to the formation of a wide range of chemical compounds.
Used in Medicinal Chemistry:
o-(piperidinocarbonyl)-benzoic acid is utilized as a reagent in medicinal chemistry for the development of new drugs, taking advantage of its chemical properties to enhance the therapeutic potential of pharmaceutical formulations.

Check Digit Verification of cas no

The CAS Registry Mumber 20320-44-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,3,2 and 0 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20320-44:
(7*2)+(6*0)+(5*3)+(4*2)+(3*0)+(2*4)+(1*4)=49
49 % 10 = 9
So 20320-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H15NO3/c15-12(14-8-4-1-5-9-14)10-6-2-3-7-11(10)13(16)17/h2-3,6-7H,1,4-5,8-9H2,(H,16,17)

20320-44-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(piperidine-1-carbonyl)benzoic acid

1.2 Other means of identification

Product number -
Other names N-Piperidino-phthalamidsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20320-44-9 SDS

20320-44-9Relevant academic research and scientific papers

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition

Sato, Ippei,Morihira, Koichiro,Inami, Hiroshi,Kubota, Hirokazu,Morokata, Tatsuaki,Suzuki, Keiko,Iura, Yosuke,Nitta, Aiko,Imaoka, Takayuki,Takahashi, Toshiya,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-ichi

, p. 8607 - 8618 (2008/12/23)

In our previous study on discovering novel types of CCR3 antagonists, we found a fluoronaphthalene derivative (1) that exhibited potent CCR3 inhibitory activity with an IC50 value of 20 nM. However, compound 1 also inhibited human cytochrome P450 2D6 (CYP2D6) with an IC50 value of 400 nM. In order to reduce its CYP2D6 inhibitory activity, we performed further systematic structural modifications on 1. In particular, we focused on reducing the number of lipophilic moieties in the biphenyl part of 1, using C log D7.4 values as the reference index of lipophilicity. This research led to the identification of N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide 1-oxide (30) which showed comparable CCR3 inhibitory activity (IC50 = 23 nM) with much reduced CYP2D6 inhibitory activity (IC50 = 29,000 nM) compared with 1.

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