20324-51-0

Basic information

• Product Name: 2-Chloro-6-mercaptobenzoic acid
• Synonyms: 2-Chloro-6-mercaptobenzoic acid;Benzoic acid, 2-chloro-6-Mercapto-;6-Chloro-2-mercaptobenzoic acid;2-Mercapto-6-Chloro Benzoic Acid
• CAS NO: 20324-51-0
• Molecular Formula: C₇H₅ClO₂S
• Molecular Weight: 188.6314
• EINECS: 1312995-182-4
• Mol File: 20324-51-0.mol

Chemical Properties

• Boiling Point: 323.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.490
• PKA: 2.35±0.36(Predicted)
• CAS DataBase Reference: 2-Chloro-6-mercaptobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-mercaptobenzoic acid(20324-51-0)
• EPA Substance Registry System: 2-Chloro-6-mercaptobenzoic acid(20324-51-0)

Safety Data

• Hazardous Substances Data: 20324-51-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Chloro-6-mercaptobenzoic acid is used as a building block in organic synthesis for the creation of various organic compounds. Its unique structure and reactivity make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
In the field of chemical research, 2-Chloro-6-mercaptobenzoic acid serves as a key intermediate for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity allows researchers to investigate its behavior in various chemical transformations, contributing to the advancement of chemical knowledge.
Used in Antibacterial Applications:
2-Chloro-6-mercaptobenzoic acid has been studied for its potential antibacterial properties. Its ability to inhibit the growth of certain bacteria makes it a candidate for further research and development as a new antimicrobial agent, particularly in the context of increasing antibiotic resistance.
Used in Anticancer Applications:
2-Chloro-6-mercaptobenzoic acid has also shown promise in anticancer research, with potential applications in the development of new cancer therapies. Its biological activities may contribute to the inhibition of cancer cell growth and the modulation of signaling pathways involved in tumor progression.
Used in Specialty Chemicals Industry:
2-Chloro-6-mercaptobenzoic acid is utilized in the specialty chemicals industry for the production of various chemical intermediates and fine chemicals. Its unique properties and reactivity make it suitable for the synthesis of compounds used in fragrances, dyes, and other specialty applications.

Synthetic route

6-chloro-2-[ethoxy(thiocarbonyl)-thio]benzoic acid (144988-64-7) → 2-chloro-6-mercapto-benzoic acid (20324-51-0)

Conditions	Yield
With sodium hydroxide In methanol

Upstream product

• 144988-64-7 6-chloro-2-[ethoxy(thiocarbonyl)-thio]benzoic acid 

Downstream Products

• 123342-93-8 2-chloro-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid 

Relevant articles and documents

Herbicidal substituted benzoylsulfonamides

Compound of the formula STR1 in which A is O, S, or NR3 ; G is CH or N; R and R1 are independently alkyl, alkoxy, haloalkoxy or alkylamino; R2 is phenyl, substituted phenyl, alkyl, cycloalkyl, haloalkyl or --CH2 [(R4)C(R5)n --Z; R3 and R7 are, independently, hydrogen, alkyl, --C(O)NH2 or --C(O)alkyl; R4 and R5 are independently hydrogen, alkyl, or halogen; R6 is halogen, alkyl, alkoxy, haloalkoxy, NO2, amino, alkyl substituted amino, or acyl substituted amino; n is 0 to 5; Z is cyano, amino, alkylamino, dialkylamino, --NHCO2 alkyl, alkoxy, alkylthio, alkylsulfonyl, alkenyl, alkynyl, phenyl or substituted phenyl; and Q is hydrogen, halogen, alkyl, alkoxy, haloalkoxy, nitro, amino, haloalkyl, alkythio, alkylsulfonyl, phenyl, substituted phenyl or phenoxy; or a 5 or 6 membered aromatic heterocycle having the formula STR2 in which "m" is 0 or 1; A' is O, S, or NR7 ; and X, X', Y, Y', W, W', V, V', U and Z' are independently N, O, S, --CH-- or --CR6. Intermediates for preparation of the benzoylsulfonamides are also disclosed.