203247-70-5Relevant academic research and scientific papers
Nickel-catalyzed α-benzylation of sulfones with esters: Via C-O activation
Xiao, Jing,Yang, Jia,Chen, Tieqiao,Han, Li-Biao
, p. 42656 - 42659 (2016)
The nickel-catalyzed α-benzylation of sulfones with readily available benzylic alcohol derivatives was achieved via C-O activation. The transformation was complete in 30 minutes using a simple Ni(COD)2 as a catalyst without any additional ligan
Palladium-catalyzed sulfination of aryl and heteroaryl halides: Direct access to sulfones and sulfonamides
Shavnya, Andrei,Coffey, Steven B.,Smith, Aaron C.,Mascitti, Vincent
supporting information, p. 6226 - 6229 (2014/01/17)
A novel palladium-catalyzed sulfination of aryl and heteroaryl halides is described. This reaction operates under mild conditions and provides access to a wide range of aryl and heteroaryl sulfinates, a useful and versatile class of synthetic intermediates. Capitalizing on this sulfination reaction, one-pot protocols allowing direct access to sulfones and sulfonamides have also been developed. The practicality of these transformations is illustrated with the parallel synthesis of analogues of the drug Viagra.
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
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, (2008/06/13)
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
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, (2008/06/13)
Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF alpha -mediated diseases, including degenerative diseases and certain cancers.
