203248-63-9Relevant academic research and scientific papers
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
-
, (2008/06/13)
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
Arylsulphonyl hydroxamic acids: Potent and selective matrix metalloproteinase inhibitors
Baxter, Andrew D,Bhogal, Ranjev,Bird, John,Keily, John F,Manallack, David T,Montana, John G,Owen, David A,Pitt, William R,Watson, Robert J,Wills, Ruth E
, p. 1465 - 1468 (2007/10/03)
A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer.
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
-
, (2008/06/13)
Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF alpha -mediated diseases, including degenerative diseases and certain cancers.
