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203258-60-0

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203258-60-0 Usage

General Description

BROSTALLICIN is a synthetic, cyclic enediyne antitumor antibiotic that is derived from the bacterium Streptomyces brostallicus. It is known for its potent cytotoxic and antitumor activity, making it a promising candidate for the treatment of various types of cancer. BROSTALLICIN works by inducing DNA damage and apoptosis in cancer cells, leading to their death. It has shown promising results in preclinical studies and is currently being investigated in clinical trials for the treatment of solid tumors, including lung, breast, and ovarian cancers. Additionally, its unique chemical structure and mechanism of action make it a valuable tool for understanding the biology of cancer and developing new anticancer drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 203258-60-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,2,5 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 203258-60:
(8*2)+(7*0)+(6*3)+(5*2)+(4*5)+(3*8)+(2*6)+(1*0)=100
100 % 10 = 0
So 203258-60-0 is a valid CAS Registry Number.

203258-60-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[[4-[[4-[[4-(2-bromoprop-2-enoylamino)-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-N-[2-(diaminomethylideneamino)ethyl]-1-methylpyrrole-2-carboxamide

1.2 Other means of identification

Product number -
Other names Brostallicin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:203258-60-0 SDS

203258-60-0Downstream Products

203258-60-0Relevant articles and documents

Cytotoxic α-bromoacrylic derivatives of distamycin analogues modified at the amidino moiety

Cozzi, Paolo,Beria, Italo,Caldarelli, Marina,Geroni, Cristina,Mongelli, Nicola,Pennella, Giulia

, p. 1273 - 1276 (2000)

The design, synthesis, in vitro and in vivo activities of novel α-bromoacrylic derivatives of distamycin A, modified at the amidino moiety by the replacement with basic or non-basic groups are reported. In spite of the relevance of these modifications of distamycin frame, the new derivatives are potent cytotoxics. The presence of the amidino moiety, is, therefore, not an absolute requirement for the activity. In particular due to a favorable myelotoxicity/cytotoxicity ratio, guanidino derivative PNU 166196 was selected for clinical development. (C) 2000 Elsevier Science Ltd. All rights reserved.

Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

-

, (2008/06/13)

Compounds which are α-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.

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