20327-23-5

Basic information

• Product Name: 1-Cyclopropylpiperazine
• Synonyms: 1-Cyclopropylpiperazine;(Piperazin-1-yl)cyclopropane;N-cyclopropylpiperazine;Cyclopropyl piperazine;Piperazine,1-cyclopropyl-
• CAS NO: 20327-23-5
• Molecular Formula: C₇H₁₄N₂
• Molecular Weight: 126.2
• EINECS: 1312995-182-4
• Product Categories: Piperazines;Pyridines
• Mol File: 20327-23-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 43°C/7mm
• Flash Point: 89.2 °C
• Appearance: /
• Density: 1.047 g/cm³
• Vapor Pressure: 0.331mmHg at 25°C
• Refractive Index: 1.4804
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.23±0.10(Predicted)
• CAS DataBase Reference: 1-Cyclopropylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropylpiperazine(20327-23-5)
• EPA Substance Registry System: 1-Cyclopropylpiperazine(20327-23-5)

Safety Data

• Hazard Codes: Xi
• RIDADR: 3267
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 20327-23-5(Hazardous Substances Data)

Usage

General Description

1-Cyclopropylpiperazine is a chemical compound with the molecular formula C6H12N2. It is a heterocyclic amine commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-Cyclopropylpiperazine is a cycloalkyl derivative of piperazine and is characterized by a cyclopropyl group attached to the piperazine ring. It is also used as a building block in the synthesis of various organic compounds due to its reactivity and ability to participate in a range of chemical reactions. 1-Cyclopropylpiperazine is a valuable compound in the field of medicinal and chemical research, and its versatile applications contribute to its importance in the chemical industry.

InChI:InChI=1/C7H14N2/c1-2-7(1)9-5-3-8-4-6-9/h7-8H,1-6H2

Upstream product

• 110694-10-5 bis-(2-sulfooxy-ethyl)-amine 
• 765-30-0 Cyclopropylamine 
• 77278-34-3 4-cyclopropylpiperazine-1-carboxylic acid tert-butyl ester 
• 159974-45-5 3-(2-Cyclopropylamino-ethyl)-oxazolidin-2-one 

Downstream Products

• 549510-57-8 4-Cyclopropylmethyl-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 1184298-24-5 5-chloro-thiophene-2-carboxylic acid [(S)-2-[3-(1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-benzenesulfonylamino]-3-(4-cyclopropyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride 
• 1184298-14-3 5-chloro-thiophene-2-carboxylic acid [(S)-2-[3-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-benzenesulfonylamino]-3-(4-cyclopropyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride 
• 1260242-70-3 C₂₈H₂₉F₆N₇ 
• 1186241-36-0 1-benzyl-4-(4-cyclopropylpiperazin-1-yl)piperidine-4-carbonitrile 
• 1190380-56-3 1-cyclopropyl-4-(5-nitropyridin-2-yl)piperazine 
• 1035271-08-9 ethyl 4-(4-cyclopropylpiperazin-1-yl)benzoate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES

The present invention is directed to a novel process for the preparation of piperazinyl and diazapanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.

1-Alkyl-4-acylpiperazines as a new class of imidazole-free histamine H 3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H3 receptor. The most potent amides had antagonist potencies in the subnanomolar range.

Use of 2-Oxazolidinones As Latent Aziridine Equivalents. III. Preparation of N-Substituted Piperazines.

A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3.The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent.The piperazines 1a-1q were isolated by crystallization in yields ranging from 23-91percent.