203302-73-2

Usage

Structure

Aromatic amine with a benzimidazole core and a chlorine substituent at the 2-position

Usage

Commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Biological activities

Studied for its potential anti-cancer and anti-inflammatory properties

Chemical reactivity

The presence of a chlorine atom can affect its interactions with other molecules, making it a valuable building block in chemical compound development

Hazards and health risks

Should be handled and used with caution due to potential hazards and health risks.

Upstream product

• 5955-72-6 2-chloro-5-nitro-1H-benzo[d]imidazole 
• 4857-06-1 2-chloro-1H-benzoimidazole 

Downstream Products

• 203302-76-5 N-(2-chlorobenzimidazol-5-yl)anthranilic acid 
• 462649-02-1 N₂,N₂-dimethyl-1H-benzo[d]imidazol-2,5-diamine 
• 85561-97-3 1H-benzo[d]imidazole-2,5-diamine 
• 832102-62-2 N²-methyl-1H-benzoimidazole-2,5-diamine 

Relevant academic research and scientific papers

COMPOUNDS FOR TREATING RESPIRATORY DISEASE

Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: Formula (I), wherein (AA) represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

SUBSTITUTED-1H-BENZO[D]IMIDAZOLE SERIES COMPOUNDS AS LYSINE-SPECFIC DEMETHYLASE 1 (LSD1) INHIBITORS

The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 ("LSD1"). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mamal an effective amount of these compounds and compositions.

Novel benzimidazole-based MCH R1 antagonists

The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.

BICYCLIC COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the formula (1) are useful as MCH mediator, and in the therapy of obesity.

Pyridinium Betaines Derived from Thiazolo and Imidazoacridinones

Four betaines derived from imidazo[4,5-a], imidazo[5,4-a] and thiazolo[5,4-a]acridine have been prepared in a six step procedure starting from 2-chlorobenzimidazoles and benzothiazoles. The 1H and 133C nmr has been used to characteri