203312-76-9

Upstream product

• 503822-33-1 (R)-2-(allylamino)-2-phenylethanol 
• 513-31-5 2-bromoallyl bromide 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 203312-80-5 Allyl-(2-bromo-allyl)-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine 
• 203312-92-9 (αR,3S)-N-(α-acetoxymethylbenzyl)-3-cyanomethyl-4-methylenepyrrolidine 
• 203312-82-7 Acetic acid (R)-2-[allyl-(2-bromo-allyl)-amino]-2-phenyl-ethyl ester 

Relevant academic research and scientific papers

Diastereocontrolled synthesis of pyrrolidines by nickel promoted tandem cyclization-quenching of aminobromodienes

The nickel promoted tandem cyclization-quenching of tethered aminobromodienes has been extended to the synthesis of 2,3,4-trisubstituted pyrrolidines. By a judicious choice of substituents on the starting aminohalodiene, the diastereoselectivity of the process can be efficiently controlled. When a chiral auxiliary on the nitrogen atom is used, enantiomerically enriched pyrrolidines can be obtained after removal of the auxiliary.