203314-50-5

Basic information

• Product Name: (2-Bromo-5-methoxy-phenyl)-acetyl chloride
• Synonyms: (2-Bromo-5-methoxy-phenyl)-acetyl chloride
• CAS NO: 203314-50-5
• Molecular Weight: 263.518
• Mol File: 203314-50-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (2-Bromo-5-methoxy-phenyl)-acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Bromo-5-methoxy-phenyl)-acetyl chloride(203314-50-5)
• EPA Substance Registry System: (2-Bromo-5-methoxy-phenyl)-acetyl chloride(203314-50-5)

Safety Data

• Hazardous Substances Data: 203314-50-5(Hazardous Substances Data)

Upstream product

• 86826-93-9 2-(2-bromo-5-methoxyphenyl)acetic acid 

Downstream Products

• 1019652-01-7 1-(4-methoxyphenyl)-2-(2-bromo-5-methoxyphenyl)ethanone 
• 143398-72-5 1-(2-Bromo-5-methoxy-benzyl)-6-methoxy-3-pentyl-1,2,3,4-tetrahydro-isoquinoline 

Relevant articles and documents

Asymmetric Total Synthesis of Hetidine-Type C20-Diterpenoid Alkaloids: (+)-Talassimidine and (+)-Talassamine

Here, we report the first asymmetric total synthesis of (+)-talassimidine and (+)-talassamine, two hetidine-type C20-diterpenoid alkaloids. A highly regio- and diastereoselective 1,3-dipolar cycloaddition of an azomethine ylide yielded a chiral tetracyclic intermediate in high enantiopurity, thus providing the structural basis for asymmetric assembly of the hexacyclic hetidine skeleton. In this key step, the introduction of a single chiral center induces four new continuous chiral centers. Another key transformation is the dearomative cyclopropanation of the benzene ring and subsequent SN2-like ring opening of the resultant cyclopropane ring with water as a nucleophile, which not only establishes the B ring but also precisely installs the difficult-to-achieve equatorial C7-OH group.

Iron and copper salts in the synthesis of benzo[b]furans

Intramolecular C-O bond forming reactions of aryl 2-bromobenzyl ketones lead to benzo[b]furans. The cyclizations can be catalyzed by 10 mol% of iron trichloride (of 98% or of 99.995% purity) or sub-mol% quantities of copper(II) chloride (of 99.995% purity

Synthesis of pyrazolo[1,5-a]indoles via copper(I)-catalyzed intramolecular amination

A variety of pyrazolo[1,5-a]indole derivatives were synthesized via Cu(I)-catalyzed intramolecular amination reactions. This novel method provides a general and efficient synthesis to indoles fused with pyrazole rings in high yields.