20332-12-1

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-octadecyl-
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-octadecyl-
• CAS NO: 20332-12-1
• Molecular Formula: C₂₆H₄₁NO₂
• Molecular Weight: 399.61
• Mol File: 20332-12-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 80-81 °C
• Boiling Point: 502 °C at 760 mmHg
• Flash Point: 180.8 °C
• Appearance: /
• Density: 0.988 g/cm³
• Vapor Pressure: 3.31E-10mmHg at 25°C
• Refractive Index: 1.51
• PKA: -2.11±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-octadecyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-octadecyl-(20332-12-1)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-octadecyl-(20332-12-1)

Safety Data

• Hazardous Substances Data: 20332-12-1(Hazardous Substances Data)

Usage

Class

Isoindole compounds

Derivative

Isoindole-1,3-dione

Hydrocarbon chain length

18 carbon atoms (octadecyl)

Industrial applications

Surfactant, emulsifier, lubricant

Uses

Production of cosmetics, pharmaceuticals, and coatings

Properties

Ability to form stable films, protective and lubricating.

InChI:InChI=1/C26H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-22-27-25(28)23-20-17-18-21-24(23)26(27)29/h17-18,20-21H,2-16,19,22H2,1H3

Upstream product

• 85-44-9 phthalic anhydride 
• 124-30-1 1-aminooctadecane 
• 136918-14-4 phthalimide 
• 3386-32-1 n-octadecyl p-toluenesulfonate 
• 131-11-3 phthalic acid dimethyl ester 
• 1074-82-4 potassium phtalimide 
• 112-89-0 1-Bromooctadecane 
• 629-93-6 n-iodooctadecane 

Downstream Products

• 223651-41-0 [2-(hydroxymethyl)phenyl]-N-octadecylformamide 
• 124-30-1 1-aminooctadecane 
• 60387-09-9 N-octadecylphthalamic acid 

Relevant articles and documents

Re-examination of microwave-induced synthesis of phthalimides

Solvent-free microwave reactions between phthalic anhydride and amino compounds need at least one liquid phase. The reaction occurs after melting of anhydride and subsequent solubilisation in amines. So, reactions between two solids may not take place and need the use of a high boiling point solvent. In all cases, excellent yields are obtained within short reaction times with products of high purity. (C) 2000 Elsevier Science Ltd.

Continuous Method For Producing Amides Of Aromatic Carboxylic Acids

The invention relates to a continuous method for producing amides of aromatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R3—OOOR4, wherein R3 represents an optionally substituted aromatic hydrocarbon group with 5 to 100 carbon atoms and R4 represents a hydrocarbon group with 1 to 30 carbon atoms, with at least one amine of formula (II) HNR1R2, wherein R1 and R2 independently represent hydrogen or a hydrocarbon group with 1 to 100 C atoms, in a reaction tube the longitudinal axis of which extends in the direction of propagation of the microwaves of a monomode microwave applicator, under microwave irradiation to form carboxamide.

Hypolipidemic activity of phthalimide derivatives. IV: Further chemical modification and investigation of the hypolipidemic activity of N-substituted imides

A further investigation of N-substituted derivatives of phthalimide for hypolipidemic activity has revealed that the chain length, as well as the type of substitution on the N-alkyl chain of phthalimide is critical for biological activity. In these studies the hypolipidemic activity was not improved by extending the chain length beyond five carbon atoms in the alkyl and alkanoic acid series. Imido nitrogen substitutents, other than alkanoic acids, methyl ketones, and alkyl groups, caused a reduction in hypolipidemic activity, e.g., hydroxy, amino, hydroxymethyl, or carbethoxy. Reduction of the keto group in the side chain to an alcohol, as well as forming derivatives of the keto group, did not improve the hypolipidemic activity with the exception of 1-N-phthalimidobutan-3-one semicarbazone. This compound demonstrated improved hypocholesterolemic activity over phthalimide and 1-N-phthalimidobutan-3-one. Substitution of the 3-position of the aromatic moiety of phthalimide with an amino or nitro group, as well as substituting a pyridine or cyclohexyl ring for the phenyl ring, led to the loss of hypolipidemic activity.