20335-27-7Relevant academic research and scientific papers
Visible Light-Induced Pericyclic Cascade Reaction for the Synthesis of Quinolinone Derivatives with an Oxabicyclo[4.2.0]octene Skeleton
Pan, Guangxing,Qin, Shaoheng,Xu, Dawen,Kühn, Fritz E.,Guo, Hao
, p. 2959 - 2963 (2021)
A photoinduced pericyclic cascade reaction has been developed to afford oxabicyclo[4.2.0]octenes. Mechanistic studies show that this reaction undergoes [2 + 2]-photocycloaddition, base-promoted elimination, retro-4π-electrocyclization, [1,5]-H shift, and
Synthesis of quinine and quinidine using sulfur ylide-mediated asymmetric epoxidation as a key step
Arshad, Muhammad,Fernandez, M. Alejandro,McGarrigle, Eoghan M.,Aggarwal, Varinder K.
experimental part, p. 1771 - 1776 (2010/10/19)
The epoxidation of meroquinene aldehyde with a chiral sulfur ylide as the key step in the synthesis of quinine and quinidine is described. The epoxidation reactions proceed under reagent control with high selectivity and good yield. The effect of sulfide and ylide substituents on the stereochemical outcome of the reaction is discussed.
Drug-induced modifications of the immune response. 12. 4,5-Dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids and derivatives as novel antiallergic agents
Mck,Zazulak,Radov,baer,Steward,Elzer,Kinsolving,Georgiev
, p. 1910 - 1918 (2007/10/02)
The synthesis of a series of novel 4,5-dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids, salts, esters, and amides is described. The title compounds when tested in the mediator-induced dermal vascular permeability and active anaphylaxis assays in rats demonstrated moderate to potent antiallergic activity. The [2-trans-(4-methyl-phenyl)cyclopropyl]amino analogue 53 emerged as the most active derivative. Thus, when administered intraperitoneally to rate at a dose of 100 mg/kg, it inhibited the action of the mediators serotonin, histamine, and bradykinin by 100%. In the active anaphylaxis assay in rats, compound 30 suppressed the edema by 81% at a dose of 100 mg/kg, following intraperitoneal administration.
Thiocyanation Reaction of Mercury(II) Complexes of Some Substituted Aromatic Acetoacetamides
Kumari, Ramesh,Dhindsa, Kuldip Singh,Taneja, A. D.
, p. 582 - 584 (2007/10/02)
Complexes of Hg(II) with acetoacetanilide (AAAH), acetoacet-ortho-toluidide (OAATH), 2,4-acetoacetxylidide (AAXH); 2,4-acetoacet-para-anisidide (PAAAH); acetoacet-para-chloroanilide (PCAAAH), ω-bromo-acetoacetanilide (ω-BrAAAH), ω-bromoacetoacet-ortho-tol
