203441-76-3Relevant academic research and scientific papers
Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams
Hulme, Christopher,Moriarty, Kevin,Huang, Fu-Chih,Mason, Jonathon,McGarry, Dan,Labaudiniere, Richard,Souness, John,Djuric, Stevan
, p. 399 - 404 (1998)
This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50's for PDE IV inhi
