203449-56-3

Upstream product

• 151259-38-0 tert-butyl diallylcarbamate 
• 161365-25-9 [(3aR,4R,5R,7aS)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-carbamic acid benzyl ester 

Downstream Products

• 203449-78-9 Bis-((S)-4-{(4R,5R)-5-[(1R,2R)-2-benzyloxycarbonylamino-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-4-hydroxy-butyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Scaffolded bis-azasugars: A dual warhead approach to glycosidase inhibition

Double Suzuki coupling was achieved with vinyl bromide 7, synthesized from the bromobenzene microbial oxidation metabolite bromocyclohexadienediol 6 and α,ω-diborane coupling partners derived from the hydroboration of the corresponding diene. Ozonolysis and selective reduction protocols served to provide selectively the α/α or β/β tethered polyhydroxylated piperidine ring systems (bis-azabugars). The C8 linked DMJ analogue 1 showed inhibitory activity against glycosidase enzymes.