2035-85-0

Basic information

• Product Name: 2-(propan-2-ylidene)propane-1,3-diol
• CAS NO: 2035-85-0
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.1583
• Mol File: 2035-85-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 239.6°C at 760 mmHg
• Flash Point: 114.6°C
• Density: 1.003g/cm³
• Vapor Pressure: 0.00695mmHg at 25°C
• Refractive Index: 1.475
• CAS DataBase Reference: 2-(propan-2-ylidene)propane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(propan-2-ylidene)propane-1,3-diol(2035-85-0)
• EPA Substance Registry System: 2-(propan-2-ylidene)propane-1,3-diol(2035-85-0)

Safety Data

• Hazardous Substances Data: 2035-85-0(Hazardous Substances Data)

Usage

General Description

2-(propan-2-ylidene)propane-1,3-diol, also known as isopropylidene glycerol, is a chemical compound with the molecular formula C6H12O3. It is a derivative of glycerol and is a colorless, odorless liquid. 2-(propan-2-ylidene)propane-1,3-diol is commonly used as a cross-linking agent in the production of resins, polymers, and plastics. It is also used as a solvent, plasticizer, and surfactant in various industrial applications. Isopropylidene glycerol has low toxicity and is considered to be relatively safe for use in consumer products.

Upstream product

• 22035-53-6 dimethyl isopropylidenemalonate 
• 6802-75-1 diethyl isopropylidenemalonate 

Downstream Products

• 16981-93-4 2-Oxo-5-isopropyliden-cyclohexan-carbonsaeure-methylester 
• 26430-97-7 1,1,5,5-Tetra-ethoxycarbonyl-3-isopropyliden-pentan 
• 16981-92-3 γ-Isopropyliden-pimelinsaeure-dimethylester 
• 26430-98-8 4-isopropylidene-heptanedioic acid 
• 327159-81-9 2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-but-2-en-1-ol 
• 310889-34-0 1-[3-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,6,6-trimethyl-cyclohexa-1,4-dienyl]-1-pyrrolidin-1-yl-methanone 
• 310889-27-1 [2-(2-benzyloxy-vinyl)-3-methyl-but-2-enyloxy]-tert-butyl-diphenyl-silane 
• 310889-25-9 3-benzyloxy-5-hydroxymethyl-2,6,6-trimethyl-cyclohexa-1,4-dienecarboxylic acid methyl ester 
• 310889-26-0 2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-but-2-enal 

Relevant articles and documents

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

Skipped cyclic ene- and dienediynes. 1. Synthesis, spectroscopic properties, and reactions of a new hydrocarbon ring family

The three skipped cyclic C12H12 dienediynes, 4,9-dimethylene-1,6-cyclodecadiyne (1), (Z,Z)-4,10-cyclododecadiene-1,7-diyne (2), and 10-methylene-(Z)-4-cycloundecene-1,7-diyne (3), have been synthesized by cyclization of dilithium salts of diterminal enediynes with the corresponding dihalogenides. This simple approach only worked (with approx. 5% yield) when no CuCl catalyst was used. Besides 1-3, 4,9-diisopropylidene-1,6-cyclodecadiyne (30), the cyclic enediynes (Z)-4-cycloundecene-1,7-diyne (19) and (Z)-4-cyclododecene-1,7-diyne (20), as well as 4-methylene-1,6-cyclodecadiyne (22), 4-methylene-1,6-cycloundecadiyne (23), and their isopropylidene congeners 25 and 28 have been synthesized. Partial hydrogenation of 1-3 gives the corresponding homoconjugated tetraenes 37-39. The reaction of 30 with dicarbonyl(η5-cyclopentadienyl)cobalt yields a superphane of two cyclobutadiene units, stabilized by two CpCo moieties (47). The two cyclobutadiene rings are connected by four 2-isopropylidenepropano bridges. An X-ray investigation of the superphane shows that all four bridges adopt a pinwheel-like conformation.