203501-32-0Relevant articles and documents
Cyclic ketone inhibitors of the cysteine protease cathepsin K
Marquis,Ru,Zeng,Lee Trout,LoCastro,Gribble,Witherington,Fenwick,Garnier,Tomaszek,Tew,Hemling,Quinn,Smith,Zhao,McQueney,Janson,D'Alessio,Veber
, p. 725 - 736 (2007/10/03)
Cathepsin K (EC 3.4.22.38), a cysteine protease of the papain superfamily, is predominantly expressed in osteoclasts and has been postulated as a target for the treatment of osteoporosis. Crystallographic and structure-activity studies on a series of acyc