203508-76-3Relevant academic research and scientific papers
Centrifugal partition chromatography: An efficient tool to access highly polar and unstable synthetic compounds on a large scale
Markovi, Dean,Barboux, Cdric,Salle De Chou, Ys,Bettach, Judith,Grougnet, Raphal,Deguin, Brigitte
, p. 63254 - 63259 (2014)
Centrifugal partition chromatography (CPC) is an efficient method adaptable for the purification of synthetic compounds with chemical value, significantly simplifying the reaction work-up. From Aucuba japonica Thunb., an abundant natural terpenoid, aucubin, was isolated. Its reduced derivatives and corresponding unstable aglucons were purified by CPC. The latter chiral synthons were obtained under protecting group free conditions using eco-friendly, non-chlorinated solvents and without silica gel.
Crossed intramolecular rauhut-currier-type reactions via dienamine activation
Marques-Lopez, Eugenia,Herrera, Raquel P.,Marks, Timo,Jacobs, Wiebke C.,Koenning, Daniel,De Figueiredo, Renata M.,Christmann, Mathias
supporting information; experimental part, p. 4116 - 4119 (2009/12/06)
The intramolecular Rauhut-Currier reaction creates a carbon-carbon bond between two tethered Michael acceptors. Previous asymmetric versions have relied on 1,4-additions of chiral nucleophilic catalysts. Herein, we Investigate a novel strategy that involves the formation of electron rich dienamines as key Intermediates. Our methodology provides an efficient entry to the iridoid framework.
Synthesis and absolute configuration of rotundial, a mosquito repellent from the leaves of vitex rotundiforia
Takikawa, Hirosato,Yamazaki, Yuichiro,Mori, Kenji
, p. 229 - 232 (2007/10/03)
The enantiomers of rotundial (1), a mosquito repellent from the leaves of Vitex rotundiforia, were synthesized from the enantiomers of limonene oxide (2). The absolute configuration of natural rotundial was determined to be R.
