203510-09-2

Upstream product

• 51248-16-9 1-(2-methyl-4-nitro-phenyl)-piperidine 
• 675-20-7 piperidin-2-one 
• 7149-70-4 2-bromo-5-nitrotoluene 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Relevant academic research and scientific papers

Multiple crystal forms of pyridine derivative, and preparation methods and application thereof

The invention specifically relates to multiple crystal forms of a compound, i.e., 1-(4-methoxyphenyl)-7-oxo-6-[2-methyl-4(2-oxotetrahydropyrrol-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, and preparation methods thereof, and application of the multiple crystal forms to preparation of drugs used for preventing or treating thrombosis or embolism, belonging to the field of chemical synthesis of drugs.

A pyridine derivative

The present invention relates to the field of pharmaceutical chemistry, specifically to a class of compounds containing lactam and derivative thereof, and especially to a pyridine derivative as shown in general formula (I), preparation method and the use thereof as a Factor Xa inhibitor. The present invention further relates to the medical use of the compound and derivative thereof in preparation of anticoagulant drugs, particularly to the use in preparation of drugs for preventing or treating thrombosis or embolism.

PROLINE DERIVATIVES

The invention relates to novel compounds of formula (I), wherein X, Y, R1, R2, R3, R4 and n have the meaning cited in claim 1, are inhibitors of the coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.

CARBONYL COMPOUNDS

The invention relates to the novel compounds of formula (I), wherein D, E, G, W, X, Y, T, R and R are defined as in claim 1. The inventive compounds inhibit coagulation factor Xa and can be used in the prophylaxis and/or therapy of thrombo-embolic diseases and for treating tumors.

The reactivity of nitrophenyl substituted cyclic amines with dehydrogenations

Piperidine and perhydroazepine bearing a 1-(4-nitrophenyl) substituent were inert to mercury-edta, while the α-pipecoline derivative gave an aminoketone with cleavage of the heterocycle. However the corresponding (2-nitrophenyl) compounds reacted to give