203519-89-5

Usage

Uses

Used in Pharmaceutical Industry:
6-(PIPERAZIN-1-YL)-4-CHLOROPYRIMIDINE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of drugs and bioactive compounds. Its structural components allow for the creation of molecules with specific therapeutic effects.
Used in Agrochemicals:
In the agrochemical sector, 6-(PIPERAZIN-1-YL)-4-CHLOROPYRIMIDINE is used as a precursor in the production of various agrochemicals, potentially aiding in the development of pesticides or other agricultural chemicals that can improve crop yields and protect against pests.
Used in Materials Science:
6-(PIPERAZIN-1-YL)-4-CHLOROPYRIMIDINE is also utilized in materials science, where it may serve as a component in the synthesis of new materials with unique properties, contributing to advances in areas such as polymers, coatings, or other specialized materials.
It is crucial to handle 6-(PIPERAZIN-1-YL)-4-CHLOROPYRIMIDINE with care due to its potential risks to human health and the environment, ensuring proper safety measures are in place throughout its use and disposal.

Upstream product

• 110-85-0 piperazine 
• 1193-21-1 4,6-dichloropyrimidine 
• 203519-88-4 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Substituted pyrimidine derivatives with Akt inhibiting activity, and preparation method and application thereof

The invention relates to novel substituted pyrimidine derivatives with Akt inhibiting activity and a preparation method thereof, a pharmaceutical composition comprising the substituted pyrimidine derivatives and salts thereof, and application of the substituted pyrimidine derivatives and salts thereof in preparing drugs for preventing and/or treating tumors. The structural formula of the compounds is disclosed as Formula (I) or Formula (II). The compounds have the advantages of novel structure, outstanding Akt inhibiting activity, high safety and low preparation cost, and have favorable application prospects in preparing antineoplastic drugs.

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.

Substituted pyrimidine derivatives and their pharmaceutical use

PCT No. PCT/GB97/02029 Sec. 371 Date Feb. 12, 1999 Sec. 102(e) Date Feb. 12, 1999 PCT Filed Jul. 25, 1997 PCT Pub. No. WO98/06705 PCT Pub. Date Feb. 19, 1998This invention concerns heterocyclic derivatives which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocyclic derivatives capable of inhibiting cholesterol biosynthesis and hence in lowering cholesterol levels in blood plasma. The present invention also relates to methods of using such heterocyclic derivatives in diseases and medical conditions such as hypercholesterolemia and atherosclerosis.