Tebanicline hydrochloride, also known as ABT-594 hydrochloride, is a potent agonist of neuronal α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs). It selectively targets α4β2 nAChRs with high affinity and demonstrates a wide range of selectivity over other neurotransmitter receptors. Tebanicline hydrochloride exhibits analgesic properties, cognitive enhancement effects, and the ability to potentiate the analgesic action of gabapentin.
203564-54-9
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Basic information
- Product Name: Tebanicline (hydrochloride)
- Synonyms: Tebanicline (hydrochloride);Tebanicline HCl;Pyridine, 5-[(2R)-2-azetidinylmethoxy]-2-chloro-, hydrochloride (1:1)
- CAS NO:203564-54-9
- Molecular Formula: C9H12Cl2N2O
- Molecular Weight: 235.11038
- EINECS: N/A
- Product Categories: N/A
- Mol File: 203564-54-9.mol
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Chemical Properties
- Melting Point: 116-117°
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Tebanicline (hydrochloride)(CAS DataBase Reference)
- NIST Chemistry Reference: Tebanicline (hydrochloride)(203564-54-9)
- EPA Substance Registry System: Tebanicline (hydrochloride)(203564-54-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 203564-54-9(Hazardous Substances Data)
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203564-54-9 Usage
Uses
Used in Pharmaceutical Industry:Tebanicline hydrochloride is used as a selective α4β2 nAChR agonist for its analgesic properties in various animal models of pain. It is particularly effective in modulating pain perception and has the potential to be developed into a therapeutic agent for pain management.
Tebanicline hydrochloride is also used as a cognitive enhancer in rodent models of attention deficit, suggesting its potential application in the treatment of cognitive disorders and improving cognitive function.
Additionally, Tebanicline hydrochloride is used to potentiate gabapentin-mediated analgesia, enhancing the effectiveness of pain relief in patients with chronic pain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 203564-54-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,5,6 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.Calculate Digit Verification of CAS Registry Number 203564-54:
(8*2)+(7*0)+(6*3)+(5*5)+(4*6)+(3*4)+(2*5)+(1*4)=109
109 % 10 = 9
So 203564-54-9 is a valid CAS Registry Number.
203564-54-9Upstream product
203564-54-9Downstream Products
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Tebanicline (hydrochloride)
