203564-54-9

Basic information

• Product Name: Tebanicline (hydrochloride)
• Synonyms: Tebanicline (hydrochloride);Tebanicline HCl;Pyridine, 5-[(2R)-2-azetidinylmethoxy]-2-chloro-, hydrochloride (1:1)
• CAS NO: 203564-54-9
• Molecular Formula: C9H12Cl2N2O
• Molecular Weight: 235.11038
• Mol File: 203564-54-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 116-117°
• Appearance: /
• CAS DataBase Reference: Tebanicline (hydrochloride)(CAS DataBase Reference)
• NIST Chemistry Reference: Tebanicline (hydrochloride)(203564-54-9)
• EPA Substance Registry System: Tebanicline (hydrochloride)(203564-54-9)

Safety Data

• Hazardous Substances Data: 203564-54-9(Hazardous Substances Data)

Usage

Description

Tebanicline hydrochloride, also known as ABT-594 hydrochloride, is a potent agonist of neuronal α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs). It selectively targets α4β2 nAChRs with high affinity and demonstrates a wide range of selectivity over other neurotransmitter receptors. Tebanicline hydrochloride exhibits analgesic properties, cognitive enhancement effects, and the ability to potentiate the analgesic action of gabapentin.

Uses

Used in Pharmaceutical Industry:
Tebanicline hydrochloride is used as a selective α4β2 nAChR agonist for its analgesic properties in various animal models of pain. It is particularly effective in modulating pain perception and has the potential to be developed into a therapeutic agent for pain management.
Tebanicline hydrochloride is also used as a cognitive enhancer in rodent models of attention deficit, suggesting its potential application in the treatment of cognitive disorders and improving cognitive function.
Additionally, Tebanicline hydrochloride is used to potentiate gabapentin-mediated analgesia, enhancing the effectiveness of pain relief in patients with chronic pain conditions.