20357-26-0Relevant academic research and scientific papers
COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
-
Page/Page column 76, (2014/01/09)
The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Concise, efficient and practical assembly of bromo-5,6-dimethoxyindole building blocks
Huleatt, Paul B.,Lau, Jacelyn,Chua, Sheena,Tan, Yun Lei,Duong, Hung Anh,Chai, Christina L.L.
, p. 1339 - 1342 (2011/03/22)
A concise, efficient and simple route to a series of bromoindole building blocks is described. The synthetic routes are highlighted by purification-free preparation of o-nitrocinnamate intermediates and clean, modified Cadogan indole syntheses. The scope of this indole synthesis has been explored and expanded through the use of a range of solvents and easily removable phosphine reagents.
