203574-98-5Relevant academic research and scientific papers
Diastereoselective nucleophilic additions to vinyl phosphine oxides
Barteis, Bjoern,Ciayden, Jonathan,Martin, Concepcion Gonzalez,Neison, Adam,Russell, Matthew G.,Warren, Stuart
, p. 1807 - 1822 (2007/10/03)
Some hydrogen, carbon, silicon, sulfur, nitrogen and oxygen nucleophiles react diastereoselectively with γ-oxygenated chiral vinyl phosphine oxides to give β-substituted phosphine oxides. Lithium N-benzyl-α-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, β-amino phosphine oxides as single diastereoisomers.
Asymmetric addition of Davies's chiral lithium amide to prochiral vinyl phosphine oxides
Bartels, Bjoern,Martin, Concepcion Gonzalez,Nelson, Adam,Russell, Matthew G.,Warren, Stuart
, p. 1637 - 1640 (2007/10/03)
Lithium N-benzyl-α-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, β-amino phosphine oxides as single diastereoisomers. A mechanism which explains the role of trimethylsilyl chloride is proposed.
