203575-01-3Relevant academic research and scientific papers
Knoevenagel Condensation of Phosphinoylacetic Acids with Aldehydes: An Efficient One-Pot Strategy for the Synthesis of P-Functionalized Alkenyl Compounds
Dziuba, Kamil,Frynas, S?awomir,Szwaczko, Katarzyna
, p. 2142 - 2154 (2021/01/21)
A wide range of commercially available aldehydes have been applied to Knoevenagel condensation reaction to give E -alkenylphosphine oxides and vinylphosphine oxides. The readily available phosphinoylacetic acids derived from P(O)-H compounds were used as the starting materials in the reaction, providing a highly stereoselective and efficient method for constructing α,β-unsaturated phosphine oxides. Moreover, this simple and practical procedure provides an alternative and more environmentally friendly synthesis strategy for this type of P-functionalized alkenyl compounds.
Cobalt catalysed, copper assisted C(sp2)-P cross coupling
Ghosh, Tubai,Maity, Pintu,Kundu, Debasish,Ranu, Brindaban C.
, p. 9556 - 9564 (2016/11/11)
An efficient protocol for the cross coupling of styrenyl/aryl halides and H-phosphinate has been developed using a unique Co/Cu catalytic system in the absence of any additional ligand for the first time. A library of diversely functionalised styrenyl/ary
Copper-catalyzed C-P coupling through decarboxylation
Hu, Jie,Zhao, Ning,Yang, Bin,Wang, Ge,Guo, Li-Na,Liang, Yong-Min,Yang, Shang-Dong
supporting information; experimental part, p. 5516 - 5521 (2011/06/21)
An acid for a phosphine: A versatile protocol for preparation of various di(phenyl)phosphoryl oxides was developed by copper-catalyzed decarboxylative coupling of alkenyl, alkynyl carboxylic acids, and N-benzylproline, respectively, with R2P(O)
Diastereoselective nucleophilic additions to vinyl phosphine oxides
Barteis, Bjoern,Ciayden, Jonathan,Martin, Concepcion Gonzalez,Neison, Adam,Russell, Matthew G.,Warren, Stuart
, p. 1807 - 1822 (2007/10/03)
Some hydrogen, carbon, silicon, sulfur, nitrogen and oxygen nucleophiles react diastereoselectively with γ-oxygenated chiral vinyl phosphine oxides to give β-substituted phosphine oxides. Lithium N-benzyl-α-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, β-amino phosphine oxides as single diastereoisomers.
Asymmetric addition of Davies's chiral lithium amide to prochiral vinyl phosphine oxides
Bartels, Bjoern,Martin, Concepcion Gonzalez,Nelson, Adam,Russell, Matthew G.,Warren, Stuart
, p. 1637 - 1640 (2007/10/03)
Lithium N-benzyl-α-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, β-amino phosphine oxides as single diastereoisomers. A mechanism which explains the role of trimethylsilyl chloride is proposed.
