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203576-34-5

3-(2-bromo-5-methoxy-phenyl)-1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-methyl-propan-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 203576-34-5 Structure

  • Basic information

    1. Product Name: 3-(2-bromo-5-methoxy-phenyl)-1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-methyl-propan-1-one
    2. Synonyms: 3-(2-bromo-5-methoxy-phenyl)-1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-methyl-propan-1-one
    3. CAS NO:203576-34-5
    4. Molecular Formula:
    5. Molecular Weight: 444.368
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 203576-34-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(2-bromo-5-methoxy-phenyl)-1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-methyl-propan-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(2-bromo-5-methoxy-phenyl)-1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-methyl-propan-1-one(203576-34-5)
    11. EPA Substance Registry System: 3-(2-bromo-5-methoxy-phenyl)-1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-methyl-propan-1-one(203576-34-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 203576-34-5(Hazardous Substances Data)

203576-34-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 203576-34-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,5,7 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 203576-34:
(8*2)+(7*0)+(6*3)+(5*5)+(4*7)+(3*6)+(2*3)+(1*4)=115
115 % 10 = 5
So 203576-34-5 is a valid CAS Registry Number.

203576-34-5Relevant articles and documents

Asymmetric conjugate addition reaction

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Page column 27, (2010/01/30)

This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.

Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist

Song, Zhiguo J.,Zhao, Mangzhu,Desmond, Richard,Devine, Paul,Tschaen, David M.,Tillyer, Richard,Frey, Lisa,Heid, Richard,Xu, Feng,Foster, Bruce,Li, Jing,Reamer, Robert,Volante, Ralph,Grabowski, Edward J. J.,Dolling, Ulf H.,Reider, Paul J.,Okada, Shigemitsu,Kato, Yoshiaki,Mano, Eiichi

, p. 9658 - 9667 (2007/10/03)

An efficient, practical, asymmetric synthesis of the endothelin receptor antagonist 1 is reported. The key pyridine-fused cyclopentane ring bearing three consecutive chiral centers was constructed by first an auxiliary induced asymmetric conjugate addition of the bottom aryllithium from 19 to an unsaturated ester 21 in high diastereoselectivity. After a highly diastereoselective addition of the top aryl Grignard reagent to the aldehyde 22, the alcohol product then underwent a stereospecific intramolecular alkylation of the ester enolate by the phosphate of the alcohol, resulting in the desired trans-trans relative stereochemistry on the cyclopentane ring. The two key chiral centers that set the chirality of the molecule were both induced from cis-1-amino-2-indanol-derived chiral auxiliaries, one in the conjugate addition reaction, the other in setting the chiral center of the bottom side chain via chiral alkylation of an enolate. Oxidation of the primary alcohol to the carboxylic acid in the bottom side chain was carried out with the newly developed TEMPO/bleach-catalyzed oxidation by sodium chlorite (NaClO2) or chromium oxide catalyzed oxidation by periodic acid. The overall process has been run successfully to make multikilograms of the drug in high purity.

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