2036044-77-4 Usage
Uses
Used in Pharmaceutical Industry:
N-((3-fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide is used as a potential drug candidate for its possible biological activity. N-((3-fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide's unique structure may contribute to its efficacy in treating various medical conditions, although the specific applications and mechanisms of action are yet to be fully explored and validated through rigorous scientific research.
Used in Materials Science:
In the field of materials science, N-((3-fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide is used as a building block for the synthesis of new materials. Its electronic or optical properties could be harnessed to create advanced materials with applications in various industries, such as electronics, photonics, or nanotechnology. The development of such materials would benefit from ongoing research into the compound's properties and how they can be manipulated or combined with other elements.
Given the complexity of the compound and the breadth of potential applications, it is essential to conduct comprehensive studies to understand its full potential and to ensure safe and effective use in practical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 2036044-77-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,3,6,0,4 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2036044-77:
(9*2)+(8*0)+(7*3)+(6*6)+(5*0)+(4*4)+(3*4)+(2*7)+(1*7)=124
124 % 10 = 4
So 2036044-77-4 is a valid CAS Registry Number.
2036044-77-4Relevant academic research and scientific papers
Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’ amide scaffold
Xu, Zhixiang,Xu, Xiangxiang,O'Laoi, Ruadhan,Ma, Haikuo,Zheng, Jiyue,Chen, Shuaishuai,Luo, Lusong,Hu, Zhilin,He, Sudan,Li, Jiajun,Zhang, Hongjian,Zhang, Xiaohu
, p. 5861 - 5872 (2016/10/30)
The Wnt signaling pathway is an essential signal transduction pathway which leads to the regulation of cellular processes such as proliferation, differentiation and migration. Aberrant Wnt signaling is known to have an association with multiple cancers. Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Here we report the synthesis and structure–activity-relationship of the novel porcupine inhibitors based on a ‘reversed’ amide scaffold. The leading compound 53 was as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Compound 53 potently inhibited the secretion of Wnt3A, therefore was confirmed to be a porcupine inhibitor. Furthermore, compound 53 showed excellent chemical and plasma stabilities. However, the clearance of compound 53 in liver microsomal tests was moderate to high, and the solubility of compound 53 was suboptimal. Collective efforts toward further optimization of this novel tricyclic template to develop better porcupine inhibitors will be subsequently undertaken and reported in due course.
