20375-18-2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 535-15-9 ethyl 1,1-dichloroacetate 
• 35768-29-7 ethyl 3-(4-chlorophenyl)-2-cyanooxirane-2-carboxylate 
• 191152-65-5 3-Chloro-3-(4-chloro-phenyl)-2-cyano-2-hydroxy-propionic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of β-chloro-α-cyano-α-hydroxyesters

Regioselective ring opening of 3-aryl-2-cyano 2-(methoxy and ethoxycarbonyl) oxiranes 1 with chlorhydric acids gave halohydrins 3 with OH, CN and CO2Me or CO2Et on the same carbon atom. - Keywords: oxirane; β-chloro-α-cyano-α-hydroxyester; ketoester; regi

REACTION OF BIS(TRIMETHYLSILOXY)PHOSPHINE WITH α-HALO CARBONYL COMPOUNDS. A NEW ROUTE TO SUBSTITUTED O,O-DIVINYL-O-TRIMETHYLSILYLPHOSPHATES

Substituted O,O-divinyl-O-trimethylsilyl phosphates 4 have been obtained in satisfactory yields by reacting bis(trimethylsiloxy)phosphine (1) with α-halo carbonyl compounds 2 in the presence of chlorotrimethylsilane and triethylamine. - Key words: Substituted O,O-divinyl-O-trimethylsilyl phosphates; substituted O-vinyl-O-trimethylsilyl-1-(trimethylsiloxy)alkylphosphonates; bis(trimethylsiloxy)phosphine; derivatives of 3-halo-2-oxoalkanoic acids; Perkow reaction.