20377-02-0Relevant academic research and scientific papers
Combinatorial synthesis of new fluorescent scaffolds using click chemistry
Cleemann, Felix,Karuso, Peter,Kum-Cheung, Wendy Loa
supporting information, (2021/12/08)
Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled using copper(I)- or ruthenium(II)- catalyzed 1,3-dipolar cycloaddition reactions. Using non-fluorescent aromatic azides and aromatic acetylenes, covering a range of electron rich and poor building blocks, the Huisgen cycloaddition afford 1,4-disubstituted or 1,5-disubstituted 1,2,3-triazoles. Using a combinatorial approach by running reaction in parallel in polypropylene 96-well plates we discovered several new fluorescent 1,2,3-triazoles scaffolds. These compounds show diverse interactions with biomolecules that could find applications in biology in, for example, fluorescence microscopy or biomolecule quantification.
Photolysis of Quinolyl Azides in Aliphatic Thiols. Synthesis of o-Alkylthioquinolylamine
Khan, Zafar U.,Nay, Barry,Scriven, Eric F.V.,Suschitsky, Hans
, p. 671 - 672 (2007/10/02)
Photolysis of 5- or 8-quinolyl azide in various thiols gives o-alkylthioquinolylamines.The beneficial effect of a 6-methoxy-group in 8-quinolyl azide on the yields is noted.
