2038-04-2

Usage

Uses

Used in Dye and Pigment Industry:
N-(2-morpholinoethyl)aniline is used as an intermediate in the production of dyes and pigments, contributing to the development of colorants for various applications.
Used in Epoxy Resin Industry:
N-(2-morpholinoethyl)aniline is used as a curing agent in the manufacturing of epoxy resins, which are essential for creating strong, durable materials used in coatings, adhesives, and electrical insulation.
Used in Polyurethane Foam Industry:
N-(2-morpholinoethyl)aniline is used as a stabilizer in the production of polyurethane foams, enhancing the stability and performance of these versatile materials used in furniture, insulation, and other applications.

Upstream product

• 110-91-8 morpholine 
• 874-78-2 N-(2-chloroethyl)aniline hydrochloride 
• 935-06-8 N-(2-chloroethyl)aniline 
• 3240-94-6 N-(2-chlorethyl)morpholine 
• 62-53-3 aniline 
• 622-40-2 2-(morpholin-4-yl)ethanol 
• 42802-94-8 4-(2-bromoethyl)morpholine hydrobromide 

Downstream Products

• 130719-57-2 3-(4-Chlorphenyl)-5-(2-morpholinoethylanilino)-4-phenyl-isoxazol 
• 130719-61-8 3-(4-Chlorphenyl)-5-(2-morpholinoethylanilino)isoxazol 
• 209333-88-0 8-(4-Benzyloxy-phenyl)-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid (2-morpholin-4yl-ethyl)-phenyl-amide 
• 101354-54-5 (2-morpholin-4-yl-ethyl)-phenyl-carbamic acid ethyl ester 
• 37152-74-2 2-bromo-N-(2-morpholin-4-yl-ethyl)-N-phenyl-propionamide 
• 100875-64-7 N-(2-morpholino-ethyl)-acetanilide 
• 92699-34-8 N-(2-morpholin-4-yl-ethyl)-N-phenyl-propionamide 
• 102164-31-8 N-(2-morpholino-ethyl)-benzanilide 

Relevant academic research and scientific papers

Nickel(II)-NΛNΛO Pincer Type Complex-Catalyzed N-alkylation of Amines with Alcohols via the Hydrogen Autotransfer Reaction

A highly sustainable catalytic protocol for the coupling of alcohols and amines for selective monoalkylated amines using Ni(II)-NΛNΛO pincer type complexes through the borrowing hydrogen methodology is described. An array of Ni(II) catalysts (1-3) was synthesized and characterized by various spectral and analytical methods. Furthermore, the distorted square planar geometry of the complexes (1 and 2) was substantiated with single crystal X-ray diffraction study. The inexpensive nickel-based catalytic methodology displays a broad substrate scope for the N-alkylation of aromatic and heteroaromatic amines using a diverse range of primary alcohols with excellent yields up to 97%. The present approach is environmentally benign, which liberates water as the sole byproduct. A short synthesis of drug intermediates such as mepyramine and chloropyramine illustrates the utility of the present protocol.

Insight into O2-promoted base-catalyzed N-alkylation of amines with alcohols

A highly efficient and practical transition-metal-free CsOH/O2 catalyst system was developed for the N-alkylation of amines with alcohols under argon. This strategy was compatible with many alcohols and exhibits excellent functional group tolerance. More significantly, the selective formation of secondary amines was achieved in excellent yields. The detailed mechanistic study gave a clear understanding of the role of base and oxygen in the catalytic cycle.

Potassium iodide catalysed monoalkylation of anilines under microwave irradiation

A potassium iodide catalysed method for the selective N-monoalkylation anilines with alkylhalides and alkyltosylates under microwave irradiation is described. The corresponding N-alkylanilines are obtained in good yields with only minor quantities of dialkylation by-products.