20383-86-2

Usage

Chemical compound

A substance formed from two or more elements chemically bonded together in a fixed proportion.

Research and drug development

The compound is used in the study and development of new drugs.

Potential antipsychotic

It may have the ability to treat mental disorders that affect mood, thinking, and behavior.

Potential anticonvulsant

It may help prevent or reduce the severity of seizures.

Piperazine ring

A six-membered ring containing two nitrogen atoms, which is a common structural feature in many pharmaceuticals.

2-chloro-phenoxy group

A chlorine atom attached to a phenoxy group (a phenol molecule with one hydroxyl group replaced by an ether linkage), which is attached to the piperazine ring.

Propyl chain

A three-carbon alkyl chain (-CH2CH2CH3) attached to the 3-position of the piperazine ring.

Central nervous system

The compound exhibits potential pharmacological activity in the brain and spinal cord.

Neurotransmitter receptors

The compound may bind to specific receptors in the brain, affecting the communication between nerve cells.

Further studies

More research is needed to fully understand the compound's therapeutic uses and safety profile.

Upstream product

• 110-85-0 piperazine 
• 50912-59-9 1-(3-bromo-propoxy)-2-chloro-benzene 

Downstream Products

• 1219027-37-8 8-chloro-11-(4-(3-(2-chlorophenoxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine 
• 1146681-45-9 3-(4-(3-(2-chlorophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol 

Relevant academic research and scientific papers

The synthesis and preliminary pharmacological evaluation of a series of substituted 4-phenoxypropyl analogues of the atypical antipsychotic clozapine

Herein we report the synthesis, characterization, and preliminary pharmacological activity of a new series of substituted 4′-phenoxypropyl tricyclic analogues of clozapine as potential antipsychotic agents for the treatment of schizophrenia. The lead comp

New azoles with potent antifungal activity: Design, synthesis and molecular docking

In response to the urgent need for novel antifungal agents with improved activity and broader spectrum, computer modeling was used to rational design novel antifungal azoles. On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of new azoles with substituted-phenoxypropyl piperazine side chains were rational designed and synthesized. In vitro antifungal activity assay indicates that the new azoles show good activity against most of the tested pathogenic fungi. Interestingly, the designed compounds are also active against an azole-resistant clinical strain. Compared to fluconazole and itraconazole, several compounds (such as 12i, 12j and 12n) show higher antifungal activity and broader spectrum, which are promising leads for the development of novel antifungal agents.

3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof

Disclosed herein are compounds of the formula STR1 in which Ar is phenyl or 1-naphthyl; R1 is hydrogen or lower alkyl; and R2 and R3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.