203871-49-2

Basic information

• Product Name: (S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one
• Synonyms: (S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one
• CAS NO: 203871-49-2
• Molecular Weight: 153.181
• Mol File: 203871-49-2.mol

Chemical Properties

• CAS DataBase Reference: (S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one(203871-49-2)
• EPA Substance Registry System: (S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one(203871-49-2)

Safety Data

• Hazardous Substances Data: 203871-49-2(Hazardous Substances Data)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 1263285-61-5 (1S,4S,5R)-4-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-2-one 
• 1817630-30-0 (3S,4S,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)-pyrrolidin-2-one 
• 1817626-54-2 PF-06650833 

Relevant articles and documents

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Photocycloaddition of α,β-unsaturated-γ-lactam with ethylene. Synthesis of conformationally restricted glutamate analogs, L-2-(2-carboxycyclobutyl)glycines

Both (2S,1'S,2'S)- and (2S, 1'S,2'R)-isomers of 2-(2-carboxycyclobutyl)glycine (CBG-I, 1b) and (CBG-III, 2b) are synthesized in a stereoselective manner via a [2+2] photocycloaddition of α,β-unsaturated-γ-lactam 3 with ethylene in acetone. The extended type of isomer 1b showed a weak activity on group II metabotropic glutamate receptors (mGluR2) of rat brain.