20389-04-2 Usage
General Description
2-M-Tolyl-quinoline-4-carboxylic acid is a chemical compound with the molecular formula C18H15NO2. It is a derivative of quinoline and is commonly used in the pharmaceutical industry as a precursor in the synthesis of various drugs. It is also known for its potential therapeutic properties, particularly in the treatment of cancer and various inflammatory diseases. The compound has been identified as a potent inhibitor of certain enzymes and receptors that are implicated in the development of cancer and inflammation. Additionally, 2-M-Tolyl-quinoline-4-carboxylic acid has shown promise in preclinical studies for its ability to modulate cellular signaling pathways that are crucial for maintaining normal physiological functions. Overall, this compound possesses significant pharmaceutical and therapeutic potential and has garnered interest in further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 20389-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,3,8 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20389-04:
(7*2)+(6*0)+(5*3)+(4*8)+(3*9)+(2*0)+(1*4)=92
92 % 10 = 2
So 20389-04-2 is a valid CAS Registry Number.
20389-04-2Relevant articles and documents
Design, synthesis and biological evaluation of 2-phenylquinoline-4-carboxamide derivatives as a new class of tubulin polymerization inhibitors
Zhu, Li,Luo, Kaixiu,Li, Ke,Jin, Yi,Lin, Jun
, p. 5939 - 5951 (2017/10/13)
A novel series of 2-phenylquinoline-4-carboxamide derivatives was synthesized, characterized and evaluated for its antiproliferative activity against five cancer cell lines, Hela, SK-OV-3, HCT116, A549 and MDA-MB-468, and a normal human fetal lung fibroblastic cell line, MRC-5. Among them, compound 7b displayed potent cytotoxic activity in vitro against SK-OV-3 and HCT116 cell lines with IC50 values of 0.5 and 0.2 μM, respectively. In general, the antiproliferative activity was correlated with the binding property of the colchicine binding site and inhibitory effect on tubulin polymerization. In addition, immunofluorescence and flow cytometry analysis revealed that selected compounds caused disruption of the mitotic spindle assembly and G2/M phase arrest of the cell cycle, which correlated with proliferation inhibitory activity. Molecular docking analysis demonstrated the interaction of 7b at the colchicine binding site of tubulin. These results indicate these compounds are promising inhibitors of tubulin polymerization for the potent treatment of cancer.