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2039-67-0

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2039-67-0 Usage

Chemical Description

3-methoxyphenethylamine and 3-methoxyphenylacetaldehyde are reactants used in the biomimetic investigation.

Chemical Properties

clear colorless to yellow liquid

Uses

3-Methoxyphenethylamine was used in the perfluorooctanesulfonic acid catalyzed Pictet-Spengler reaction. It was also used in the synthesis of 1,3-oxazepines via palladium-catalyzed intramolecular coupling.

General Description

The spectral binding affinity for 3-methoxyphenethylamine was studied to examine the determinants of P450 2D6 catalysis.

Check Digit Verification of cas no

The CAS Registry Mumber 2039-67-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,3 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2039-67:
(6*2)+(5*0)+(4*3)+(3*9)+(2*6)+(1*7)=70
70 % 10 = 0
So 2039-67-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO/c1-11-9-4-2-3-8(7-9)5-6-10/h2-4,7H,5-6,10H2,1H3/p+1

2039-67-0 Well-known Company Product Price

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  • TCI America

  • (M1891)  2-(3-Methoxyphenyl)ethylamine  >98.0%(GC)(T)

  • 2039-67-0

  • 5g

  • 650.00CNY

  • Detail
  • TCI America

  • (M1891)  2-(3-Methoxyphenyl)ethylamine  >98.0%(GC)(T)

  • 2039-67-0

  • 25g

  • 2,890.00CNY

  • Detail
  • Alfa Aesar

  • (H64494)  2-(3-Methoxyphenyl)ethylamine, 97+%   

  • 2039-67-0

  • 5g

  • 235.0CNY

  • Detail
  • Alfa Aesar

  • (H64494)  2-(3-Methoxyphenyl)ethylamine, 97+%   

  • 2039-67-0

  • 25g

  • 817.0CNY

  • Detail
  • Alfa Aesar

  • (H64494)  2-(3-Methoxyphenyl)ethylamine, 97+%   

  • 2039-67-0

  • 100g

  • 2940.0CNY

  • Detail

2039-67-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-methoxyphenyl)ethanamine

1.2 Other means of identification

Product number -
Other names 2-(3-Methoxyphenyl)ethylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2039-67-0 SDS

2039-67-0Relevant articles and documents

-

Boekelheide,V.,Chang,M.Y.

, p. 1303 - 1307 (1964)

-

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds

Vara, Brandon A.,Levi, Samuel M.,Achab, Abdelghani,Candito, David A.,Fradera, Xavier,Lesburg, Charles A.,Kawamura, Shuhei,Lacey, Brian M.,Lim, Jongwon,Methot, Joey L.,Xu, Zangwei,Xu, Haiyan,Smith, Dustin M.,Piesvaux, Jennifer A.,Miller, J. Richard,Bittinger, Mark,Ranganath, Sheila H.,Bennett, David J.,Dimauro, Erin F.,Pasternak, Alexander

supporting information, p. 653 - 661 (2021/04/12)

Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase, is a negative immune regulator of T cell receptor (TCR) and B cell signaling that is primarily expressed in hematopoietic cells. Accordingly, it has been reported that HPK1 loss-of-function in HPK1 kinase-dead syngeneic mouse models shows enhanced T cell signaling and cytokine production as well as tumor growth inhibition in vivo, supporting its value as an immunotherapeutic target. Herein, we present the structurally enabled discovery of novel, potent, and selective diaminopyrimidine carboxamide HPK1 inhibitors. The key discovery of a carboxamide moiety was essential for enhanced enzyme inhibitory potency and kinome selectivity as well as sustained elevation of cellular IL-2 production across a titration range in human peripheral blood mononuclear cells. The elucidation of structure-activity relationships using various pendant amino ring systems allowed for the identification of several small molecule type-I inhibitors with promising in vitro profiles.

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

Henry, Martyn C.,Senn, Hans Martin,Sutherland, Andrew

, p. 346 - 364 (2019/01/08)

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.

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