20395-98-6Relevant academic research and scientific papers
METHOD AND MEANS FOR MANUFACTURING TERPENE INDOLE ALKALOIDS
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Page/Page column 10; 31, (2019/10/04)
The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene indole alkaloid derivative, comprising the steps of: (1) providing a terpene indole alkaloid; and (2) providing a first enzyme termed "Precondylocarpine Acetate Synthase" (PAS) or a functional variant or homologue thereof; and/or a second enzyme termed "Dehydroprecondylocarpine Acetate Synthase" (DPAS) or a functional variant or homologue thereof, and optionally providing further identified enzymes involved in this pathway. The invention also encompasses related kits, enzymes, expression vectors, host cells and plants.
NEW BIS-INDOLE ALKALOIDS AS ANTICANCER DRUGS
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Page/Page column 17, (2014/12/12)
The field of this invention relates to novel cyclopropyl derivatives of the general formula (I) representing pharmaceutically applicable Vinca Rosea type alkaloid compounds, particularly having a cytostatic effect. The invention also is concerned processes for preparing these new alkaloids and their pharmacological compositions and the use of these compounds in treatment of cancer. R stands for a methyl or a formyl group, R1 stands for a methoxy or an amino group, R2 represents a hydroxy or acetoxy group, R3 stands for a hydrogen atom or a hydroxy group, R4 represents a hydrogen atom or R3 and R4 together represent a double bond, R5 and R6 represent hydrogen or fluorine atoms n = 1 or 2.
COMPOSES ANTITUMORAUX DU GROUPE DE LA VINBLASTINE: NOUVELLE METHODE DE PREPARATION
Andriamialisoa, R. Z.,Langlois, N.,Langlois, Y.,Potier, P.
, p. 3053 - 3060 (2007/10/02)
7'-Chloro-indolenines from several dimeric alkaloids of vinblastine type are useful intermediates in the preparation of antitumor derivatives belonging to seco-5',6' and nor-5'series.
