204-03-5

Basic information

• Product Name: 1H-NAPHTHO[1,8-DE][1,2,3]TRIAZINE
• Synonyms: 1H-NAPHTHO[1,8-DE][1,2,3]TRIAZINE
• CAS NO: 204-03-5
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.18
• Mol File: 204-03-5.mol
• Article Data: 21

Chemical Properties

• Melting Point: 258-262 °C (decomp)
• Boiling Point: 351.9 °C at 760 mmHg
• Flash Point: 166.6 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 3.99E-05mmHg at 25°C
• Refractive Index: 1.758
• PKA: -6.47±0.20(Predicted)
• CAS DataBase Reference: 1H-NAPHTHO[1,8-DE][1,2,3]TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-NAPHTHO[1,8-DE][1,2,3]TRIAZINE(204-03-5)
• EPA Substance Registry System: 1H-NAPHTHO[1,8-DE][1,2,3]TRIAZINE(204-03-5)

Safety Data

• Hazardous Substances Data: 204-03-5(Hazardous Substances Data)

Usage

General Description

1H-Naphtho[1,8-de][1,2,3]triazine is a chemical compound that belongs to the class of naphthotriazine derivatives. It is a heterocyclic compound containing a naphthalene and a triazine ring system. 1H-Naphtho[1,8-de][1,2,3]triazine has potential applications in the field of organic electronics, as it can be used as an electron transporting material in organic photovoltaic devices. It has also been studied for its potential use as a fluorescent probe for the detection of metal ions in biological and environmental samples. Additionally, 1H-Naphtho[1,8-de][1,2,3]triazine has been investigated for its anti-tumor and anti-cancer activities, showing promise as a possible therapeutic agent in the treatment of various types of cancer.

InChI:InChI=1/C10H7N3/c1-3-7-4-2-6-9-10(7)8(5-1)11-13-12-9/h1-6H,(H,11,12)

Upstream product

• 479-27-6 naphthalene-1,8-diamine 
• 110-46-3 isopentyl nitrite 
• 40237-01-2 2-methyl-2H-naphto<1,8-de>triazine 

Downstream Products

• 75526-83-9 C₁₉H₁₁N₃O₂ 
• 17135-74-9 1,8-dibromonaphthalene 
• 1094554-10-5 6,8-dimethyl-1,2,3,7-tetraazapyrene 
• 1174205-45-8 6,8-di(4-nitrophenyl)-1,2,3,7-tetraazapyrene 
• 5690-48-2 naphthalene-1,8-dicarbonitrile 
• 73399-88-9 8-Chlornaphthalin-1-carbonitril 
• 59107-51-6 8-chloronaphthalen-1-amine 
• 52753-62-5 1-amino-8-iodonaphthalene 
• 157735-41-6 8-iodonaphthalene-1-carbonitrile 
• 1413473-81-0 8-phenyl-3,8-dihydropyrido[2',3',4':4,5]naphtho[1,8-de][1,2,3]triazin-7(6H)-one 
• 1413473-82-1 8-(4-bromophenyl)-3,8-dihydropyrido[2',3',4':4,5]naphtho[1,8-de][1,2,3]triazin-7(6H)-one 
• 1413473-83-2 8-(4-nitrophenyl)-3,8-dihydropyrido[2',3',4':4,5]naphtho[1,8-de][1,2,3]triazin-7(6H)-one 
• 13638-84-1 1,2-diphenyl-acenaphthylene 
• 1632078-27-3 methyl 4-(2-phenylacenaphthylen-1-yl)benzoate 

Relevant articles and documents

5,11-Diazadibenzo[hi,qr]tetracene: Synthesis, Properties, and Reactivity toward Nucleophilic Reagents

5,11-Diazadibenzo[hi,qr]tetracene was synthesized as a new nitrogen-substituted polycyclic heteroaromatic compound by Pd-catalyzed cycloisomerization of an alkyne precursor followed by oxidative cyclization with bis(trifluoroacetoxy)iodobenzene. The substitution of imine-type nitrogen atoms significantly enhanced its electron-accepting character and facilitated the direct nucleophilic addition of arylamines under strongly basic conditions to afford the desired amino-substituted products. The introduction of amino groups induced a remarkable red-shift in their absorption spectra; the tetrasubstituted product exhibited intense near-infrared absorbing property. Furthermore, the π-electronic system, which includes a redox-active 1,4-diazabutadiene moiety, underwent reversible interconversion to its corresponding reduced form upon reduction with NaBH4 and aerobic oxidation.

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Multi-layer 3D chirality: new synthesis, AIE and computational studies

New synthesis of multi-layer 3D chiral molecules has been developed under novel conditions to give better outcomes. The aggregation-induced emission (AIE), UV irradiation/excitation, charge transfer (CT) and local excited (LE) ππ* transitions have been investigated on a representative individual enantiomer of pseudo C2 asymmetry which was made possibly by differentiating moieties on phosphorous on N-phosphonyl ring of chiral sandwich framework. Meanwhile, a new tandem C-N/C-C coupling reaction was unexpectedly rendered providing a novel access to special benzo[a]carbazoles.