20404-02-8 Usage
Classification
Chlorinated phenol and nitrophenol
Common Uses
Fungicide
Wood preservative
Manufacturing of dyes
Manufacturing of pharmaceuticals
Hazards
Considered a hazardous substance
Potential environmental and health impacts
Health Effects
Irritation to the skin, eyes, and respiratory tract upon exposure
Long-term exposure linked to adverse effects on the liver and kidneys
Environmental Impact
Highly toxic to aquatic organisms
Persistent in the environment, leading to potential contamination of water bodies
Importance of Proper Handling and Disposal
Crucial to minimize negative impacts on both human health and the environment
Check Digit Verification of cas no
The CAS Registry Mumber 20404-02-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,0 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 20404-02:
(7*2)+(6*0)+(5*4)+(4*0)+(3*4)+(2*0)+(1*2)=48
48 % 10 = 8
So 20404-02-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H2Cl3NO3/c7-2-1-3(10(12)13)4(8)5(9)6(2)11/h1,11H
20404-02-8Relevant articles and documents
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
Shiohara, Hiroaki,Nakamura, Tetsuya,Kikuchi, Norihiko,Ozawa, Tomonaga,Nagano, Ryuichi,Matsuzawa, Akane,Ohnota, Hideki,Miyamoto, Takahide,Ichikawa, Kazuo,Hashizume, Kiyoshi
experimental part, p. 3622 - 3634 (2012/07/27)
Thyromimetics that specifically target TRβ have been shown to reduce plasma cholesterol levels and avoid atherosclerosis through the promotion of reverse cholesterol transport in an animal model. We designed novel thyromimetics with high receptor (TRβ) and organ (liver) selectivity based on the structure of eprotirome (3) and molecular modeling. We found that indane derivatives are potent and dual-selective thyromimetics expected to avoid hypothyroidism in some tissues as well as heart toxicity. KTA-439 (29), a representative indane derivative, showed the same high human TRβ selectivity in a binding assay as 3 and higher liver selectivity than 3 in a cholesterol-fed rat model.
