20405-96-3Relevant academic research and scientific papers
Efficient asymmetric hydrogenation of α-amino ketone derivatives. A highly enantioselective synthesis of phenylephrine, levamisole, carnitine and propranolol
Sukuraba,Takahashi,Takeda,Achiwa
, p. 738 - 747 (2007/10/02)
The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I) were found to be efficient catalysts for asymmetric hydrogenation of α-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active β-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.
EFFICIENT ASYMMETRIC HYDROGENATION OF α-AMINOACETOPHENONE DERIVATIVES LEADING TO PRACTICAL SYNTHESIS OF (S)-(-)-LEVAMISOLE
Takeda, Hideo,Tachinami, Takeshi,Aburatani, Masakazu,Takahashi, Hisashi,Morimoto, Toshiaki,Achiwa, Kazuo
, p. 363 - 366 (2007/10/02)
The neutral (2S,4S)-MCCPM-rhodium complex was found to be an efficient catalyst for asymmetric hydrogenation of α-aminoacetophenone derivatives.A practical asymmetric synthesis of (S)-(-)-levamisole was realized by using this hydrogenation as a key reaction.
