204062-03-3

Basic information

• Product Name: 5-[3-(2-Aminoethoxy)-1-propynyl]-2',3'-dideoxy-cytidine 5'-(tetrahydrogen triphosphate)
• Synonyms: 5-[3-(2-Aminoethoxy)-1-propynyl]-2',3'-dideoxy-cytidine 5'-(tetrahydrogen triphosphate)
• CAS NO: 204062-03-3
• Molecular Formula: C14H23N4O13P3
• Molecular Weight: 548.272703
• Mol File: 204062-03-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.94±0.1 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 5-[3-(2-Aminoethoxy)-1-propynyl]-2',3'-dideoxy-cytidine 5'-(tetrahydrogen triphosphate)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[3-(2-Aminoethoxy)-1-propynyl]-2',3'-dideoxy-cytidine 5'-(tetrahydrogen triphosphate)(204062-03-3)
• EPA Substance Registry System: 5-[3-(2-Aminoethoxy)-1-propynyl]-2',3'-dideoxy-cytidine 5'-(tetrahydrogen triphosphate)(204062-03-3)

Safety Data

• Hazardous Substances Data: 204062-03-3(Hazardous Substances Data)

Relevant articles and documents

Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same

Substituted propargylethoxyamido nucleosides are disclosed having the structure STR1 wherein X is selected from the group consisting of amino alkanoic acid, alkylamino benzoic acid, α-amino acid, and 4-amino-2-butynoic acid. R1 and R2 taken separately are selected from the group consisting of --H, lower alkyl, protecting group, and label; R3 is selected from the group consisting of --H and lower alkyl. B is a 7-deazapurine, purine, or pyrimidine nucleoside base. When B is purine or 7-deazapurine, the sugar moiety is attached at the N9 -position of the purine or deazapurine, and when B is pyrimidine, the sugar moiety is attached at the N1 -position of the pyrimidine. When B is a purine, the adjacent triple-bonded carbon is attached to the 8-position of the purine, when B is 7-deazapurine, the adjacent triple-bonded carbon is attached to the 7-position of the 7-deazapurine, and when B is pyrimidine, the adjacent triple-bonded carbon is attached to the 5-position of the pyrimidine. W1 is selected from the group consisting of --H and --OH. W2 is --OH or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3'-position. W3 is selected from the group consisting of --PO4, --P2 O7, --P3 O10, phosphate analog, and --OH. Additionaly, a primer extension method is provided employing the above X-substituted propargylethoxyamido nucleosides, and polynucleotides including the above X-substituted propargylethoxyamido nucleosides is provided.