204065-18-9Relevant academic research and scientific papers
CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS
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, (2008/06/13)
A compound of the formula: wherein R 1 and R 2 each represents hydrogen, lower alkyl which may be substituted or acyl; R 3, R 4 and R 5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R 4 and R 5 taken together represent a 5-or 6-membered carbocyclic group; R 6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5-to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH 2, COCH 2, OCH 2, SCH 2, NHCH 2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.
Synthesis of TAK-218 using (R)-2-methylglycidyl tosylate as a chiral building block
Fukatsu, Kohji,Fujii, Nobuhiro,Ohkawa, Shigenori
, p. 1521 - 1526 (2007/10/03)
We performed an asymmetric synthesis of (S)-2,3-dihydro-2,4,6,7- tetramethyl-2-[(4-phenyl-1-piperidinyl)-methyl]-5-benzofuranamine dihydrochloride (TAK-218, 1), a compound used for the treatment of traumatic and ischemic central nervous system injuries. O
