204205-90-3

Basic information

• Product Name: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
• Synonyms: Indibulin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;lindiblin;Nascapine;ZIO 301;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
• CAS NO: 204205-90-3
• Molecular Formula: C22H16ClN3O2
• Molecular Weight: 389.83
• Product Categories: Anticancer.
• Mol File: 204205-90-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.31 g/cm³
• Refractive Index: 1.664
• Storage Temp.: Desiccate at -20°C
• PKA: 9.38±0.70(Predicted)
• CAS DataBase Reference: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide(204205-90-3)
• EPA Substance Registry System: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide(204205-90-3)

Safety Data

• Hazardous Substances Data: 204205-90-3(Hazardous Substances Data)

Usage

Uses

Indibulin is a microtubule destabilizer. Acts as a chemotherapeutic drug used in the treatment of breast cancer and other heterogenous and aggressive types of cancer.

Biological Activity

Microtubule destabilizer that blocks tubulin polymerization (IC 50 = 0.3 μ M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC 50 values ranging from 0.036-0.285 μ M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo . Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

InChI:InChI=1/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28)