204267-20-9Relevant academic research and scientific papers
Benzyl 2-cyano-3,3-dimethyl-1-pyrrolidinecarboxylate, a versatile intermediate for the synthesis of 3,3-dimethylproline derivatives
Medina, Jesus R.,Blackledge, Charles W.,Erhard, Karl F.,Axten, Jeffrey M.,Miller, William H.
, p. 3946 - 3949 (2008/09/19)
(Chemical Equation Presented) The synthesis of racemic nitrile (±)-9 was accomplished in four steps and 58% overall yield from the known pyrrolidinone 5. Nitrile (±)-9 was resolved via preparative chiral HPLC to afford optically pure nitriles (+)-9 and (-
Thrombin inhibitors
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, (2008/06/13)
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. where R3 is —CH2NH2, —CH2CH2NH2, or —CH2NHC(O)OC(CH3)3.
Histidine derivatives
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, (2008/06/13)
Compounds of the formula STR1 wherein R, R1, R2, R3 and R4 represent certain specified substituent groups. The compounds exhibit activity in the reserpine induced hypothermia test.
