204326-24-9Relevant articles and documents
Conformationally constrained peptidomimetic inhibitors of Signal transducer and activator of transcription 3: Evaluation and molecular modeling
Mandal, Pijus K.,Limbrick, Donald,Coleman IV, David R.,Dyer, Garrett A.,Ren, Zhiyong,Birtwistle, J. Sanderson,Xiong, Chiyi,Chen, Xiaomin,Briggs, James M.,McMurray, John S.
experimental part, p. 2429 - 2442 (2010/03/01)
Signal transducer and activator of transcription 3 (Stat3) is involved in aberrant growth and survival signals in malignant tumor cells and is a validated target for anticancer drug design. We are targeting its SH2 domain to prevent docking to cytokine an